(2S)-2-tert-butoxy-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(4-phenoxybutanamido)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid | 1454611-31-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (2S)-2-tert-butoxy-2-(7-(8-fluoro-5-methylchroman-6-yl)-5-methyl-2-(4-phenoxybutanamido)pyrazolo[1,5-a]pyrimidin-6-yl)acetic acid
• 英文别名: (2S)-2-[7-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-5-methyl-2-(4-phenoxybutanoylamino)pyrazolo[1,5-a]pyrimidin-6-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid
• CAS: 1454611-31-4
• 化学式: C₃₃H₃₇FN₄O₆
• 分子量: 604.678
• InChiKey: LPEJCVXAASADEE-HKBQPEDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  44
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Inhibitors of Human Immunodeficiency Virus Replication
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20130237499A1

  公开（公告）日：2013-09-12

  The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

  该披露通常涉及到公式I的化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。该披露提供了HIV的新型抑制剂，包含这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
• LUBRICATING OIL COMPOSITION FOR SLIDING SECTION COMPRISING ALUMINUM MATERIAL, AND LUBRICATING METHOD
  申请人：JX Nippon Oil & Energy Corporation

  公开号：EP2653528A1

  公开（公告）日：2013-10-23

  Provided are a lubricant composition capable of reducing friction between sliding parts at least one of which contains an aluminum-based material in a lubrication section, and a method for lubricating an aluminum-based member with the composition. The lubricant composition is for use in a lubrication section having sliding parts at least one of which contains an aluminum-based material, and contains a lubricant base oil and at least one of a phosphorus-containing carboxylic compound and a metal salt thereof (component (A)) at 0.001 to 1 mass% of the composition in terms of phosphorus. The composition may suitably be used as lubricant such as drive train lubricant for automatic or manual transmissions, grease, wet brake oil, hydraulic actuation oil, turbine oil, compressor oil, bearing oil, refrigerant oil, and the like used in apparatus having the sliding parts.

  本发明提供了一种能够减少滑动部件之间摩擦的润滑剂组合物，滑动部件中至少有一个含有铝基材料，本发明还提供了一种使用该组合物润滑铝基部件的方法。该润滑剂组合物用于具有至少一个含有铝基材料的滑动部件的润滑部分，并含有润滑剂基础油和至少一种含磷羧酸化合物及其金属盐（成分 (A)），以磷计，占组合物的 0.001 至 1 质量％。该组合物可适当用作润滑剂，如自动或手动变速箱的传动系统润滑剂、润滑脂、湿式制动油、液压驱动油、涡轮机油、压缩机油、轴承油、冷冻机油等，用于具有滑动部件的设备中。
• INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
  申请人：Bristol-Myers Squibb Company

  公开号：EP2822950A1

  公开（公告）日：2015-01-14
• US9006235B2
  申请人：——

  公开号：US9006235B2

  公开（公告）日：2015-04-14
• US9040470B2
  申请人：——

  公开号：US9040470B2

  公开（公告）日：2015-05-26