1-(2-methoxyphenyl)-1-oxo-2-aza-4,4-diethyl-4-(naphth-1-yl)-butane | 265656-00-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(2-methoxyphenyl)-1-oxo-2-aza-4,4-diethyl-4-(naphth-1-yl)-butane
• 英文别名: N-(2-ethyl-2-naphthalen-1-ylbutyl)-2-methoxybenzamide
• CAS: 265656-00-6
• 化学式: C₂₄H₂₇NO₂
• 分子量: 361.484
• InChiKey: ZJXUOFVIUFVURR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• BENZAMIDE POTASSIUM CHANNEL INHIBITORS
  申请人：Merck & Co., Inc.

  公开号：EP1126836A1

  公开（公告）日：2001-08-29
• EP1126836A4
  申请人：——

  公开号：EP1126836A4

  公开（公告）日：2002-09-04
• US6194458B1
  申请人：——

  公开号：US6194458B1

  公开（公告）日：2001-02-27
• [EN] BENZAMIDE POTASSIUM CHANNEL INHIBITORS<br/>[FR] INHIBITEURS BENZAMIDIQUES DE CANAUX POTASSIQUES
  申请人：MERCK & CO INC

  公开号：WO2000025774A1

  公开（公告）日：2000-05-11

  This invention relates to benzamide potassium channel inhibitors of general structural formula (I). The compounds of this invention are useful in the treatment of autoimmune diseases, the prevention of rejection of foreign organ transplants and related afflictions, diseases and illnesses, and cardiac arrhythmias. Also within the scope of this invention are pharmaceutical formulations comprising a compound of formula (I) and a pharmaceutical carrier, as well as pharmaceutical formulations comprising a compound of formula (I), one or more immunosuppressive compounds and a pharmaceutical carrier.