(Z)-1-(2-ethoxyvinyl)-4-methylnaphthalene | 1542270-00-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (Z)-1-(2-ethoxyvinyl)-4-methylnaphthalene
• CAS: 1542270-00-7
• 化学式: C₁₅H₁₆O
• 分子量: 212.291
• InChiKey: IPFVLOZLCHARGP-KHPPLWFESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.16
• 重原子数：
  16.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.23
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  1-溴-4-甲基萘 、 三丁基(2-乙氧基乙烯基)锡 在 三乙烯二胺 、 (Bis(tri-tert-butylphosphine)palladium⁽⁰⁾) 、 SPGS-550-M; NOK 、 sodium chloride 作用下， 以 水 为溶剂， 反应 18.0h， 以84%的产率得到(Z)-1-(2-ethoxyvinyl)-4-methylnaphthalene
  参考文献：
  名称：

  “Nok”: A Phytosterol-Based Amphiphile Enabling Transition-Metal-Catalyzed Couplings in Water at Room Temperature

  摘要：

  The third-generation designer amphiphile/surfactant, "Nok" (i.e., SPGS-550-M; beta-sitosterol methoxypolyethyleneglycol succinate), soon to be commercially available from Aldrich, can be prepared in two steps using an abundant plant feedstock and beta-sitosterol, together with succinic anhydride and PEG-550-M. Upon dissolution in water, it forms nanomicelles that serve as nanoreactors, which can be characterized by both cryo-TEM and dynamic light scattering analyses. Several transition-metal-catalyzed reactions have been run under micellar conditions to evaluate this surfactant relative to results obtained in nanoparticles composed of TPGS-750-M (i.e., a second-generation surfactant). It is shown that Nok usually affords yields that are, in general, as good or better than those typically obtained with TPGS-750-M, and yet is far less costly.

  DOI：

  10.1021/jo401744b