N-(5-phenyl-3-pyridylmethyl)-N-(2-chromanyl-methyl)-amine | 177975-02-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N-(5-phenyl-3-pyridylmethyl)-N-(2-chromanyl-methyl)-amine
• 英文别名: 1-(Chroman-2-yl)-N-((5-phenylpyridin-3-yl)methyl)methanamine；1-(3,4-dihydro-2H-chromen-2-yl)-N-[(5-phenylpyridin-3-yl)methyl]methanamine
• CAS: 177975-02-9
• 化学式: C₂₂H₂₂N₂O
• 分子量: 330.429
• InChiKey: IXWSVBPAGSIIHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  34.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Amino(thio)ether derivatives as CNS active agents
  申请人：MERCK PATENT GmbH

  公开号：EP0707007A1

  公开（公告）日：1996-04-17

  Amino(thio)ether derivatives of formula I wherein R°, R¹, R², R³, R⁶, R⁷, R⁸, R⁹, X and Z are as defined in Claim 1, and their salts, are active on the central nervous system.

  式 I 的氨基（硫代）醚衍生物 其中 R°、R¹、R²、R³、R⁶、R⁷、R⁸、R⁹、X 和 Z 如权利要求 1 所定义，它们的盐类对中枢神经系统具有活性。
• 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chromane as CNS active agent
  申请人：MERCK PATENT GmbH

  公开号：EP1123933A1

  公开（公告）日：2001-08-16

  2-[5-(4-fluorophenyl)-3-pyridyl-methylaminomethyl]-chromane and its physiologically acceptable salts thereof and (S)-(+)-2-[5-(4-fluorophenyl)-3-pyridyl-methylaminomethyl]-chromane and its physiologically acceptable salts thereof are active on the central nervous system.

  2-[5-(4-氟苯基)-3-吡啶基-甲基氨基甲基]-色烷及其生理学上可接受的盐类和(S)-(+)-2-[5-(4-氟苯基)-3-吡啶基-甲基氨基甲基]-色烷及其生理学上可接受的盐类对中枢神经系统具有活性。
• 5 HT RECEPTOR MEDIATED NEUROGENESIS
  申请人：Barlow Carrolee

  公开号：US20100009983A1

  公开（公告）日：2010-01-14

  The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on use of a 5HTR agent, in combination with one or more other neurogenic agents, or anti-astrogenic agent, to stimulate or activate the formation of new nerve cells.
• US5767132A
  申请人：——

  公开号：US5767132A

  公开（公告）日：1998-06-16
• US7618988B2
  申请人：——

  公开号：US7618988B2

  公开（公告）日：2009-11-17