N-(2-chlorobenzyl)-5-(1H-indazol-5-yl)isooxazole-3-carboxamide | 1093306-07-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: N-(2-chlorobenzyl)-5-(1H-indazol-5-yl)isooxazole-3-carboxamide
• 英文别名: N-(2-chlorobenzyl)-5-(1H-indazol-5-yl)isoxazole-3-carboxamide；N-[(2-chlorophenyl)methyl]-5-(1H-indazol-5-yl)-1,2-oxazole-3-carboxamide
• CAS: 1093306-07-0
• 化学式: C₁₈H₁₃ClN₄O₂
• 分子量: 352.78
• InChiKey: TXDOWJLFZWXTCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• QUINOLINE CARBOXYLIC ACID-O,O BIS-ACYLOXY BORATE AND PROCESS OF MAKING
  申请人：SATYANARAYANA CHAVA

  公开号：US20090259041A1

  公开（公告）日：2009-10-15

  The intermediate (4aS-Cis)-1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-me-thoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid-O 3 ,O 4 )bis(acyloxy-0) borate and a method of preparation. The intermediate is useful in an improved process for the preparation of moxifloxacin hydrochloride from ethyl 1-cyclopropyl 6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate.

  中间体(4aS-Cis)-1-环丙基-7-(2,8-二氮杂双环[4.3.0]壬-8-基)-6-氟-8-甲氧基-4-氧代-1,4-二氢-3-喹啉羧酸-O3,O4)双(酰氧-0)硼酸盐及其制备方法。该中间体可用于改进的从乙酰基1-环丙基6,7-二氟-8-甲氧基-4-氧代-1,4-二氢-3-喹啉羧酸乙酯制备莫西沙星盐酸盐的过程中。
• Novel therapeutic compounds
  申请人：Breinlinger Eric C.

  公开号：US20090069288A1

  公开（公告）日：2009-03-12

  Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases as well as proliferative disorders such as cancer.

  本文公开了公式（I）的新化合物，其中变量如本文所定义。公式（I）的化合物可用作激酶抑制剂，因此可用于治疗某些疾病和病症，特别是炎症性疾病和疾病以及增生性疾病，如癌症。
• 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS
  申请人：Akritopoulou-Zanze Irini

  公开号：US20090203690A1

  公开（公告）日：2009-08-13

  The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R 1 , R 2 , R 3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Cdc7, AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.

  本发明涉及式（I）的化合物或药物可接受的盐，其中A，R1，R2，R3和m在说明书中定义。本发明还涉及制备所述化合物的方法，以及含有所述化合物的组合物，该组合物对抑制激酶如糖原合成酶激酶3（GSK-3），Rho激酶（ROCK），Janus激酶（JAK），Cdc7，AKT，PAK4，PLK，CK2，KDR，MK2，JNK1，极光激酶，pim 1和nek 2有用。
• 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS
  申请人：Abbott Laboratories

  公开号：EP2167491A1

  公开（公告）日：2010-03-31
• US20140343066A1
  申请人：——

  公开号：US20140343066A1

  公开（公告）日：2014-11-20