[1,2-diamino-1,2-bis(3-methoxyphenyl)ethane](dichloro)platinum(II) | 93856-30-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: [1,2-diamino-1,2-bis(3-methoxyphenyl)ethane](dichloro)platinum(II)
• 英文别名: 1,2-Bis(3-methoxyphenyl)ethane-1,2-diamine;dichloroplatinum
• CAS: 93856-30-5
• 化学式: C₁₆H₂₀Cl₂N₂O₂Pt
• 分子量: 538.333
• InChiKey: QHVPWJARCAUNQD-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  3.78
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  70.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [1,2-diamino-1,2-bis(3-methoxyphenyl)ethane](dichloro)platinum(II) 、 13,17-bis(2-carboxyethyl)-3,8-bis[1-(ethyleneglycolmonoethylether)oxyethyl]-2,7,12,18-tetramethylporphin 在 sodium hydroxide 、 silver nitrate 作用下， 以 甲醇 、 水 为溶剂， 以51%的产率得到[1,2-diamino-1,2-bis(3-methoxyphenyl)ethane-N,N'](13,17-bis(2-carboxylatoethyl)-3,8-bis[1-(ethyleneglycolmonoethylether)oxyethyl]-2,7,12,18-tetramethylporphin-O,O')platinum(II)
  参考文献：
  名称：

  New porphyrin platinum conjugates for the cytostatic and photodynamic tumor therapy

  摘要：

  The combination of a porphyrin system and a platinum fragment in the same molecule should not only result in the additivity of the photodynamic activity of the porphyrin and the cytostatic activity of the platinum, but also in the enrichment of the porphyrin platinum conjugate in tumors, which platinum compounds alone do not show. New porphyrin platinum conjugates were obtained from the platinum complexes of a series of 1,2-diamines and hematoporphyrin or 13,17-bis(2-carboxyethyl)-3,8-bis [1-(ethyleneglycolmonoethylether)oxvethyl]-2,7,12,18-tetramethylporphin. The 1,2-diamines were synthesized starting from the corresponding stilbenes via 1,2-diazides. The new platinum porphyrin conjugates showed promising antitumor activity in tests with the mammary carcinoma cell line MDA-MB-231. (C) 2003 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(02)01490-1
• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 1,2-diamino-1,2-bis(3-methoxyphenyl)ethane dihydrochloride 在 sodium hydroxide 作用下， 以 水 为溶剂， 以64%的产率得到[1,2-diamino-1,2-bis(3-methoxyphenyl)ethane](dichloro)platinum(II)
  参考文献：
  名称：

  New porphyrin platinum conjugates for the cytostatic and photodynamic tumor therapy

  摘要：

  The combination of a porphyrin system and a platinum fragment in the same molecule should not only result in the additivity of the photodynamic activity of the porphyrin and the cytostatic activity of the platinum, but also in the enrichment of the porphyrin platinum conjugate in tumors, which platinum compounds alone do not show. New porphyrin platinum conjugates were obtained from the platinum complexes of a series of 1,2-diamines and hematoporphyrin or 13,17-bis(2-carboxyethyl)-3,8-bis [1-(ethyleneglycolmonoethylether)oxvethyl]-2,7,12,18-tetramethylporphin. The 1,2-diamines were synthesized starting from the corresponding stilbenes via 1,2-diazides. The new platinum porphyrin conjugates showed promising antitumor activity in tests with the mammary carcinoma cell line MDA-MB-231. (C) 2003 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(02)01490-1