1-amino-1-(1-naphthyl)-2-methyl-2-propanol | 741733-38-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-amino-1-(1-naphthyl)-2-methyl-2-propanol
• 英文别名: 1-amino-2-methyl-1-naphthalen-1-ylpropan-2-ol
• CAS: 741733-38-0
• 化学式: C₁₄H₁₇NO
• 分子量: 215.295
• InChiKey: MZVRGFKUZCPPMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-amino-1-(1-naphthyl)-2-methyl-2-propanol 、 N-甲酰-L-苯丙氨酸 以 异丙醇 为溶剂， 生成 (S)-1-amino-2-methyl-1-(naphthalen-1-yl)propan-2-ol formyl-L-phenylalaninate
  参考文献：
  名称：

  OPTICALLY ACTIVE BISOXAZOLINE COMPOUNDS, PROCESS FOR PRODUCTION OF THE SAME AND USE THEREOF

  摘要：

  公开号：

  EP1593674B1
• 作为产物：
  描述：

  1-(trifluoroacetylamino)-1-(1-naphthyl)-2-methyl-2-propanol 在 氢氧化钾 、 乙醇 、 水 、 异丙醇 作用下， 反应 2.5h， 生成 1-amino-1-(1-naphthyl)-2-methyl-2-propanol
  参考文献：
  名称：

  OPTICALLY ACTIVE BISOXAZOLINE COMPOUNDS, PROCESS FOR PRODUCTION OF THE SAME AND USE THEREOF

  摘要：

  公开号：

  EP1593674B1

文献信息

• Optically active bisoxazoline compounds, process for production of the same and use thereof
  申请人：Itagaki Makoto

  公开号：US20060149077A1

  公开（公告）日：2006-07-06

  Optically active bisoxazoline compounds represented by the general formula (1), a process for producing the compounds, and a process for producing cyclopropanecarboxylic esters by using the same: wherein R 1 and R 2 are the same and each represents C 1-6 alkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted phenyl or R 1 and R 2 are bonded each other together with the carbon atom of oxazoline ring to which they are bonded to form a ring; R 3 is substituted or unsubstituted naphthyl; R 4 and R 5 are the same and each represent hydrogen or C 1-6 alkyl, or R 4 and R 5 are bonded each other together with the carbon atom to which they are bonded to form a cycloalkyl ring having 3 to 6 carbon atoms; and * represents an asymmetric center.

  光学活性的双噁唑啉化合物由通式（1）表示，制备该化合物的方法以及使用该化合物制备环丙烷羧酸酯的方法： 其中，R1和R2相同，分别表示C1-6烷基，取代或未取代的芳基烷基或取代或未取代的苯基，或者R1和R2相互结合形成环，与它们所连接的噁唑环的碳原子相连；R3是取代或未取代的萘基；R4和R5相同，分别表示氢或C1-6烷基，或者R4和R5相互结合形成有3至6个碳原子的环状烷基环；*表示一个不对称中心。
• METHOD FOR PRODUCING OPTICALLY ACTIVE BISAMIDO ALCOHOL COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1698616A1

  公开（公告）日：2006-09-06

  It is provided that a method for producing an optically active bisamidoalcohol compound represented by the formula (3): wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl group, an optionally substituted aralkyl group or a hydrogen atom, or two R1s, which are bonded to the same carbon atom, are bonded to form a ring together with the carbon atom to which they are bonded, R2 represents a C1-6 alkyl group, an optionally substituted phenyl group, a 1-naphthyl group, a 2-naphthyl group or an optionally substituted aralkyl group, R3 and R4 are the same or different, and each represents a hydrogen atom or C1-3 alkyl group, m represents an integer of 0 to 2, and * represents an asymmetric center, which comprises reacting an optically active aminoalcohol compound represented by the formula (1): wherein R1, R2 and * are as defined above, with a diester compound represented by the formula (2): wherein R3, R4 and m are as defined above and R5 represents a C1-3 alkyl group, in the presence of a lithium compound.

  本发明提供了一种生产由式（3）代表的光学活性双氨基醇化合物的方法： 其中 R1 代表 C1-6 烷基、任选取代的苯基、任选取代的芳烷基或氢原子，或两个 R1 与同一碳原子键合，与其键合的碳原子一起形成环、 R2 代表 C1-6 烷基、任选取代的苯基、1-萘基、2-萘基或任选取代的芳基、 R3 和 R4 相同或不同，各自代表氢原子或 C1-3 烷基、 m 代表 0 至 2 的整数，以及 * 代表不对称中心，其中包括与由式（1）代表的光学活性氨基醇化合物反应： 其中 R1、R2 和 * 如上定义、 与式 (2) 所代表的二酯化合物反应： 其中 R3、R4 和 m 如上定义，R5 代表 C1-3 烷基、 在锂化合物存在下。
• Method for producing optically active bisamidoalcohol compound
  申请人：Itagaki Makoto

  公开号：US20070100163A1

  公开（公告）日：2007-05-03

  It is provided that a method for producing an optically active bisamidoalcohol compound represented by the formula (3): wherein R 1 represents a C1-6 alkyl group, an optionally substituted phenyl group, an optionally substituted aralkyl group or a hydrogen atom, or two R 1 s, which are bonded to the same carbon atom, are bonded to form a ring together with the carbon atom to which they are bonded, R 2 represents a C1-6 alkyl group, an optionally substituted phenyl group, a 1-naphthyl group, a 2-naphthyl group or an optionally substituted aralkyl group, R 3 and R 4 are the same or different, and each represents a hydrogen atom or C1-3 alkyl group, m represents an integer of 0 to 2, and * represents an asymmetric center, which comprises reacting an optically active aminoalcohol compound represented by the formula (1): wherein R 1 , R 2 and * are as defined above, with a diester compound represented by the formula (2): wherein R 3 , R 4 and m are as defined above and R 5 represents a C1-3 alkyl group, in the presence of a lithium compound.
• US7288674B2
  申请人：——

  公开号：US7288674B2

  公开（公告）日：2007-10-30
• US7612236B2
  申请人：——

  公开号：US7612236B2

  公开（公告）日：2009-11-03