triethyl(6-(3-fluorophenyl)naphthalen-2-yl)silane | 1554400-78-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: triethyl(6-(3-fluorophenyl)naphthalen-2-yl)silane
• 英文别名: Triethyl-[6-(3-fluorophenyl)naphthalen-2-yl]silane；triethyl-[6-(3-fluorophenyl)naphthalen-2-yl]silane
• CAS: 1554400-78-0
• 化学式: C₂₂H₂₅FSi
• 分子量: 336.524
• InChiKey: QVEHGRNCKIUZKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.36
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6-(3-Fluorophenyl)naphthalen-2-ol 在 copper (II)-fluoride 、 bis(1,5-cyclooctadiene)nickel (0) 、 三乙胺 、 cesium fluoride 、 三环己基膦 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 生成 triethyl(6-(3-fluorophenyl)naphthalen-2-yl)silane
  参考文献：
  名称：

  A Mild Ni/Cu-Catalyzed Silylation via C–O Cleavage

  摘要：

  A Ni/Cu-catalyzed silylation of unactivated C-O electrophiles derived from phenols or benzyl alcohols is described. This transformation is characterized by its wide scope and mild conditions, providing a direct access to synthetically versatile silylated compounds. The protocol allows for the coupling of C(sp(2))-O and even C(sp(3))-O bonds with similar efficiency.

  DOI：

  10.1021/ja412107b

文献信息

• A Mild Ni/Cu-Catalyzed Silylation via C<i>–</i>O Cleavage
  作者：Cayetana Zarate、Ruben Martin

  DOI：10.1021/ja412107b

  日期：2014.2.12

  A Ni/Cu-catalyzed silylation of unactivated C-O electrophiles derived from phenols or benzyl alcohols is described. This transformation is characterized by its wide scope and mild conditions, providing a direct access to synthetically versatile silylated compounds. The protocol allows for the coupling of C(sp(2))-O and even C(sp(3))-O bonds with similar efficiency.