3,3-dimethyl-1,2-dihydrobenzo[f]chromene-1,2-diol | 174480-97-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 3,3-dimethyl-1,2-dihydrobenzo[f]chromene-1,2-diol
• CAS: 174480-97-8
• 化学式: C₁₅H₁₆O₃
• 分子量: 244.29
• InChiKey: TUJHLRNFVSGTHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  18.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.69
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  3,3-二甲基苯并[F]色烯 在 Mn(III)salen <(R,R)-4> sodium hypochlorite 作用下， 以 二氯甲烷 为溶剂， 以38%的产率得到3,3-dimethyl-1,2-dihydrobenzo[f]chromene-1,2-diol
  参考文献：
  名称：

  Enantiomerically Pure Epoxychromans via Asymmetric Catalysis

  摘要：

  A practical and highly effective process for the asymmetric epoxidation of several 2,2-dimethylchromene derivatives is reported. Catalysis by Mn(salen) complex 4 in all cases affords epoxychromans with > 90% ee, and this method has been applied to the synthesis of two recently developed antihypertensive agents in enantiomerically pure form.

  DOI：

  10.1016/s0040-4039(00)93426-9

文献信息

• Enantiomerically Pure Epoxychromans via Asymmetric Catalysis
  作者：Nam Ho Lee、Alexander R. Muci、Eric N. Jacobsen

  DOI：10.1016/s0040-4039(00)93426-9

  日期：1991.9

  A practical and highly effective process for the asymmetric epoxidation of several 2,2-dimethylchromene derivatives is reported. Catalysis by Mn(salen) complex 4 in all cases affords epoxychromans with > 90% ee, and this method has been applied to the synthesis of two recently developed antihypertensive agents in enantiomerically pure form.