2-{N-[2-(1-naphthoylamino)ethyl]}aminomethyl-2,3-dihydrobenzo[b]furan | 175902-93-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-{N-[2-(1-naphthoylamino)ethyl]}aminomethyl-2,3-dihydrobenzo[b]furan
• 英文别名: N-[2-(2,3-dihydro-1-benzofuran-2-ylmethylamino)ethyl]naphthalene-1-carboxamide
• CAS: 175902-93-9
• 化学式: C₂₂H₂₂N₂O₂
• 分子量: 346.429
• InChiKey: QDKVKPLTNWQSDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NOVEL 2,3-DIHYDROBENZOFURAN DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0769496A1

  公开（公告）日：1997-04-23

  Disclosed are a 2,3-dihydrobenzofuran derivative represented by formula (1) or a salt thereof, a method for producing the same, and use thereof:    wherein R1 represents a hydrogen atom or a lower alkyl group; R2 represents a naphthyl group, a pyridyl group, a furyl group or a thienyl group; n is an integer of from 2 to 6; A represents a carbonyl group or a sulfonyl group; and * represents an asymmetric carbon atom. The 2,3-dihydrobenzofuran derivatives of the present invention and the non-toxic salts thereof have a strong affinity for serotonin 1A receptors. Therefore, are useful as pharmaceutical composition containing the 2,3-dihydrobenzofuran derivatives and the non-toxic salts thereof are especially useful for treating a serotonergic neuron-related disease, such as anxiety, depression, eating disorder, high blood pressure, emesis (including emesis induced by motion sickness, space sickness, dizziness and drug, etc.) and the like.

  本发明公开了式(1)代表的2,3-二氢苯并呋喃衍生物或其盐、生产方法及其用途： 其中 R1 代表氢原子或低级烷基；R2 代表萘基、吡啶基、呋喃基或噻吩基；n 为 2 至 6 的整数；A 代表羰基或磺酰基；* 代表不对称碳原子。 本发明的 2,3-二氢苯并呋喃衍生物及其无毒盐对血清素 1A 受体有很强的亲和力。因此，作为含有 2,3-二氢苯并呋喃衍生物及其无毒盐的药物组合物，特别适用于治疗与血清素能神经元有关的疾病，如焦虑、抑郁、饮食失调、高血压、呕吐（包括晕车、晕船、晕眩和药物等引起的呕吐）等。
• Process for producing alkyl 3-amino-4-substituted benzoates
  申请人：Sankio Chemical Co., Ltd.

  公开号：EP0853077A1

  公开（公告）日：1998-07-15

  A process for producing an alkyl 3-amino-4-substituted benzoate represented by the following formula (II) is described, in which a 3-amino-4-substituted benzoic acid or an alkali metal salt thereof represented by the following formula (I) is allowed to react with an alkyl halide in the presence of a basic carbonate: wherein R represents an alkyl group, X represents an alkali metal atom or a hydrogen atom, and Y represents an alkoxy group or a halogen atom.

  本发明描述了一种生产下式(II)代表的 3-氨基-4-取代苯甲酸烷基酯的工艺，在该工艺中，允许下式(I)代表的 3-氨基-4-取代苯甲酸或其碱金属盐在碱式碳酸盐存在下与烷基卤化物反应： 其中 R 代表烷基，X 代表碱金属原子或氢原子，Y 代表烷氧基或卤素原子。
• US5798382A
  申请人：——

  公开号：US5798382A

  公开（公告）日：1998-08-25