diphenyl (naphthalen-1-yl(phenylamino)methyl)phosphine oxide | 102480-03-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: diphenyl (naphthalen-1-yl(phenylamino)methyl)phosphine oxide
• 英文别名: -diphenyl-phosphinoxid
• CAS: 102480-03-5
• 化学式: C₂₉H₂₄NOP
• 分子量: 433.489
• InChiKey: RGKOJXDIAAAOFO-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  1-萘甲醛 、 苯胺 、 Diphenylphosphine oxide 在 silver hexafluoroantimonate 作用下， 以 neat (no solvent) 为溶剂， 反应 6.5h， 以80%的产率得到diphenyl (naphthalen-1-yl(phenylamino)methyl)phosphine oxide
  参考文献：
  名称：

  Silver‐Catalyzed One‐Pot Three‐Component Synthesis of α‐Aminonitriles and Biologically Relevant α‐Amino‐phosphonates

  摘要：

  AbstractA simple silver salt (AgSbF6)‐catalyzed aminophosphonylation and Strecker reaction have been developed and successfully applied to a wide range of substrates (>55 substrates). This solvent‐, ligand‐, and base‐free one‐pot three‐component protocol operates effectively at room temperature to provide diversified α‐aminophosphonates and α‐aminonitriles, which gave access to the respective α‐amino amides. Importantly, the present catalyst system is also capable to produce the rarely reported and biologically relevant aminophosphonates (having anti‐leishmanial activity). Further, mechanistic studies reveal that the present phosphonylation protocol follows a radical pathway.

  DOI：

  10.1002/asia.202200703