rac-4-(3-hydroxy-2,2-dimethylpropyl)-1,3-dioxolan-2-one | 1142951-96-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: rac-4-(3-hydroxy-2,2-dimethylpropyl)-1,3-dioxolan-2-one
• 英文别名: 4-(3-hydroxy-2,2-dimethylpropyl)-1,3-dioxolan-2-one
• CAS: 1142951-96-9
• 化学式: C₈H₁₄O₄
• 分子量: 174.197
• InChiKey: BJIDWWSGDFZCRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  、 3-乙酰氨基丙烷-1-磺酰氯 、 rac-4-(3-hydroxy-2,2-dimethylpropyl)-1,3-dioxolan-2-one 、 三乙胺 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 以60 mg (21% yield) of the title compound (14) was obtained as a colorless oil的产率得到rac-2,2-dimethyl-3-(2-oxo(1,3-dioxolan-4-yl))propyl [3-(acetylamino)propyl]sulfonate
  参考文献：
  名称：

  Internally Masked Neopentyl Sulfonyl Ester Cyclization Release Prodrugs of Acamprosate, Compositions Thereof, and Methods of Use

  摘要：

  本文介绍了内部掩蔽的新戊基磺酰酯前药，这些前药包括乙酰丙胺酸的制药组合物，并且介绍了使用这些前药和组合物治疗疾病的方法。具体来说，介绍了具有增强口服生物利用度的乙酰丙胺酸前药，并介绍了使用乙酰丙胺酸前药治疗神经退行性疾病、精神障碍、情绪障碍、焦虑障碍、躯体形式障碍、运动障碍、物质滥用障碍、暴食障碍、皮层扩散性抑郁相关障碍、耳鸣、睡眠障碍、多发性硬化症和疼痛的方法。

  公开号：

  US20090099253A1
• 作为产物：
  描述：

  rac-4-[2,2-dimethyl-3-(1,1,2,2-tetramethyl-1-silapropoxy)propyl]-1,3-dioxolan-2-one 在 triethylamine tris(hydrogen fluoride) 作用下， 以 四氢呋喃 为溶剂， 以36%的产率得到rac-4-(3-hydroxy-2,2-dimethylpropyl)-1,3-dioxolan-2-one
  参考文献：
  名称：

  Internally Masked Neopentyl Sulfonyl Ester Cyclization Release Prodrugs of Acamprosate, Compositions Thereof, and Methods of Use

  摘要：

  内部掩盖的新戊基磺酰酯前药，包含这种前药的药物组合物，以及使用这种前药和组合物治疗疾病的方法被披露。具体来说，披露了展现增强口服生物利用度的阿卡姆普罗酸前药以及使用阿卡姆普罗酸前药治疗神经退行性疾病、精神障碍、情绪障碍、焦虑障碍、躯体形式障碍、运动障碍、物质滥用障碍、暴饮暴食障碍、皮层扩散性抑郁相关障碍、耳鸣、睡眠障碍、多发性硬化症和疼痛的方法。

  公开号：

  US20090099253A1

文献信息

• Electrocoating composition including an anti-crater agent
  申请人：AXALTA COATING SYSTEMS IP CO., LLC

  公开号：US10577510B2

  公开（公告）日：2020-03-03

  An electrocoating composition is provided herein. The electrocoating composition includes an aqueous carrier. The electrocoating composition further includes a film forming binder. The film forming binder includes an epoxy-amine adduct and a blocked polyisocyanate crosslinking agent. The electrocoating composition further includes an anti-crater agent selected from the group of a polyester resin dispersion, a polyacrylate resin dispersion, and a combination thereof. The electrocoating composition further includes a supplemental anti-crater agent including a polyether modified polysiloxane.

  本文提供了一种电涂层组合物。电涂层组合物包括水性载体。电涂层组合物还包括成膜粘合剂。成膜粘合剂包括环氧胺加合物和封端多异氰酸酯交联剂。电涂层组合物还包括一种防缩孔剂，选自聚酯树脂分散体、聚丙烯酸酯树脂分散体及其组合。电涂层组合物还包括一种补充抗缩孔剂，包括聚醚改性聚硅氧烷。
• Cathodic electrocoating compositions containing an anti-crater agent
  申请人：Gam Allisa

  公开号：US20060084725A1

  公开（公告）日：2006-04-20

  An improved aqueous cathodic electrocoating composition that contains an anti-crater agent which is a water-reducible polyester resin having an acid value less than 40 mg KOH/g. The water-reducible polyester is the reaction product of (1) a hydroxy cyclic carbonate; (2) a polycarboxylic acid anhydride; (3) optional monofunctional epoxy resin; (4) a polyfunctional isocyanate resin; and, (5) a polyamine compound containing tertiary amine and either primary or secondary functionality. The reaction product is neutralized in the presence of acid and water to convert the tertiary amine groups to water-dilutable groups. Hydrolyzable silane groups can also be incorporated into the reaction product to further enhance its crater resistance property. The electrocoat composition produces coatings having a smoother appearance with fewer craters without adversely affecting intercoat adhesion of the cured film to subsequent coating layers applied thereover.

  一种改进的水性阴极电涂层组合物，其中含有一种防缩孔剂，它是一种酸值小于 40 毫克 KOH/g 的水溶性聚酯树脂。该水还原性聚酯是以下物质的反应产物：(1) 环碳酸羟酯；(2) 聚羧酸酐；(3) 任选的单官能环氧树脂；(4) 多官能异氰酸酯树脂；以及 (5) 含有叔胺和伯胺或仲胺官能团的多胺化合物。反应产物在酸和水的存在下进行中和，将叔胺基团转化为可稀释的水基。可水解硅烷基团也可加入反应产物中，以进一步增强其抗缩孔性能。这种电涂层组合物生产出的涂层外观更平滑，凹坑更少，同时不会对固化薄膜与后续涂层的层间附着力产生不利影响。
• CATHODIC ELECTROCOATING COMPOSITIONS CONTAINING AN ANTI-CRATER AGENT
  申请人：E. I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP1831317B1

  公开（公告）日：2008-03-05
• ELECTROCOATING COMPOSITON INCLUDING AN ANTI-CRATER AGENT
  申请人：AXALTA COATING SYSTEMS IP CO., LLC

  公开号：US20180282557A1

  公开（公告）日：2018-10-04

  An electrocoating composition is provided herein. The electrocoating composition includes an aqueous carrier. The electrocoating composition further includes a film forming binder. The film forming binder includes an epoxy-amine adduct and a blocked polyisocyanate crosslinking agent. The electrocoating composition further includes an anti-crater agent selected from the group of a polyester resin dispersion, a polyacrylate resin dispersion, and a combination thereof. The electrocoating composition further includes a supplemental anti-crater agent including a polyether modified polysiloxane.
• US7264706B2
  申请人：——

  公开号：US7264706B2

  公开（公告）日：2007-09-04