racemic-(±)-4,4'-((ethane-1,2-diylbis(4,1-phenylene))bis(methylene))bis(1-(hydroxymethyl)-5,7-dimethyl-2,3-dithia-5,7-diazabicyclo[2.2.2]octane-6,8-dione) | 1427176-89-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: racemic-(±)-4,4'-((ethane-1,2-diylbis(4,1-phenylene))bis(methylene))bis(1-(hydroxymethyl)-5,7-dimethyl-2,3-dithia-5,7-diazabicyclo[2.2.2]octane-6,8-dione)
• 英文别名: (±)-4,4'-((ethane-1,2-diylbis(4,1-phenylene))bis(methylene))bis(1-(hydroxymethyl)-5,7-dimethyl-2,3-dithia-5,7-diazabicyclo[2.2.2]octane-6,8-dione)；(±)-4,4'-((ethane-1,2-diyldi(4,1-phenylene))di(methylene))di(1-(hydroxymethyl)-5,7-dimethyl-2,3-dithia-5,7-diazabicyclo[2.2.2]octane-6,8-dione)；4,4'-((ethane-1,2-diyldi(4,1-phenylene))di(methylene))di(1-(hydroxymethyl)-5,7-dimethyl-2,3-dithia-5,7-diazabicyclo[2.2.2]octane-6,8-dione)；1-(Hydroxymethyl)-4-[[4-[2-[4-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]octan-1-yl]methyl]phenyl]ethyl]phenyl]methyl]-5,7-dimethyl-2,3-dithia-5,7-diazabicyclo[2.2.2]octane-6,8-dione
• CAS: 1427176-89-3
• 化学式: C₃₀H₃₄N₄O₆S₄
• 分子量: 674.887
• InChiKey: YVDMZGMWMJONGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  223
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Compositions and Methods for Inhibiting Activity of Hypoxia-Inducible Transcription Factor Complex and Its Use for Treatment of Tumors
  申请人：University of Southern California

  公开号：US20150246933A1

  公开（公告）日：2015-09-03

  Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and translation of hypoxia-inducible genes.

  本发明涉及一种二硫代二酮哌嗪化合物、基于其的制药组合物以及用于治疗、减少或抑制缺氧诱导基因转录和翻译的方法。
• EPIDITHIODIKETOPIPERAZINE COMPOUNDS, COMPOSITIONS, AND METHODS
  申请人：Globavir Biosciences, Inc.

  公开号：US20150284349A1

  公开（公告）日：2015-10-08

  Epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of their synthesis, as part of treating, inhibiting and reducing transcription and translation of hypoxia inducible genes are described.

  本文描述了Epidithiodiketopiperazine化合物、基于此的制药组合物以及它们的合成方法，作为治疗、抑制和减少缺氧诱导基因转录和翻译的一部分。
• COMPOSITIONS AND METHODS FOR INHIBITING ACTIVITY OF HYPOXIA-INDUCIBLE TRANSCRIPTION FACTOR COMPLEX AND ITS USE FOR TREATMENT OF TUMORS
  申请人：University Of Southern California

  公开号：EP2890382B1

  公开（公告）日：2017-10-25
• US9416145B2
  申请人：——

  公开号：US9416145B2

  公开（公告）日：2016-08-16