7-[(2-methoxy)-3-pyridyl]-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline | 338998-73-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 7-[(2-methoxy)-3-pyridyl]-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
• 英文别名: 7-(2-methoxypyridin-3-yl)-2-methyl-4-phenyl-3,4-dihydro-1H-isoquinoline
• CAS: 338998-73-5
• 化学式: C₂₂H₂₂N₂O
• 分子量: 330.429
• InChiKey: YYPYTOFXNPHCJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
  申请人：Molino F. Bruce

  公开号：US20060111394A1

  公开（公告）日：2006-05-25

  The present invention relates to a method of treating disorders by administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula (I): wherein R 1 -R 8 are as described herein, R 4 being aryl or heteroaryl.

  本发明涉及一种通过向需要此类治疗的病人施用式(I)化合物的治疗有效量来治疗疾病的方法： 其中R1-R8如本文所述，R4为芳基或杂芳基。
• Aryl and heteroaryl substituted tetrahydroisoquinolines and use thereof
  申请人：——

  公开号：US20020143014A1

  公开（公告）日：2002-10-03

  Provided herein are compounds of the formula (I): 1 wherein R 1 -R 8 are as described herein, R 4 being aryl or heteroaryl Such compounds are particularly useful in the treatment of a disorder which is created by or is dependent upon decreased availability of serotonin, norepinephrine or dopamine.

  本文提供了式(I)的化合物：其中R1-R8如本文所述，R4为芳基或杂环基。这些化合物在治疗由于或依赖于血清素、去甲肾上腺素或多巴胺可用性降低所引起的疾病中特别有用。
• Use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence
  申请人：——

  公开号：US20040248932A1

  公开（公告）日：2004-12-09

  Provided herein are methods of using compounds of formula (1) that are aryl- and heteroaryl-substituted tetrahydroisoquinolines, for the treatment of chronic and neuropathic pain, the treatment and prevention of migraine headache, and the treatment of stress, urge and mixed urinary incontinence.

  本文提供了使用芳基和杂芳基取代的四氢异喹啉的式 (1) 化合物治疗慢性和神经性疼痛、治疗和预防偏头痛以及治疗压力性、急迫性和混合性尿失禁的方法。
• ARLY- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN
  申请人：ALBANY MOLECULAR RESEARCH, INC.

  公开号：EP1246806A1

  公开（公告）日：2002-10-09
• ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN
  申请人：AMR Technology, Inc.

  公开号：EP1819337A2

  公开（公告）日：2007-08-22