2,3-bis(4-nitrophenoxy)naphthalene-1,4-dione | 1301627-09-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,3-bis(4-nitrophenoxy)naphthalene-1,4-dione
• CAS: 1301627-09-7
• 化学式: C₂₂H₁₂N₂O₈
• 分子量: 432.346
• InChiKey: DYEUHGXQUSWSCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  144
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CARCINOMA<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'UN CARCINOME DE LA PROSTATE
  申请人：PELLFICURE PHARMACEUTICALS INC

  公开号：WO2016040896A1

  公开（公告）日：2016-03-17

  Disclosed herein are 1,4-naphthoquinone analogs, pharmaceutical compositions that include one or more of such 1,4-naphthoquinone analogs, and methods of treating and/or ameliorating diseases and/or conditions associated with a cancer, such as prostate cancer with such 1,4-naphthoquinone analogs. Also included are combination therapies wherein a 1,4-naphthoquinone analog disclosed herein, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.

  披露的是1,4-萘醌类似物，包括一个或多个这样的1,4-萘醌类似物的药物组合物，以及使用这些1,4-萘醌类似物治疗和/或改善与癌症相关的疾病和/或状况的方法，例如前列腺癌。还包括组合疗法，其中向患有癌症等状况的主体提供在本发明中披露的1,4-萘醌类似物和激素治疗剂。
• Compositions and methods for treatment of prostate carcinoma
  申请人：Pellficure Pharmaceuticals, Inc.

  公开号：US10093620B2

  公开（公告）日：2018-10-09

  Disclosed herein are 1,4-naphthoquinone analogs, pharmaceutical compositions that include one or more of such 1,4-naphthoquinone analogs, and methods of treating and/or ameliorating diseases and/or conditions associated with a cancer, such as prostate cancer with such 1,4-naphthoquinone analogs. Also included are combination therapies wherein a 1,4-naphthoquinone analog disclosed herein, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.

  本文公开了1,4-萘醌类似物、包括一种或多种此类1,4-萘醌类似物的药物组合物，以及用此类1,4-萘醌类似物治疗和/或改善与癌症（如前列腺癌）相关的疾病和/或病症的方法。还包括组合疗法，其中向患有癌症等疾病的受试者提供本文公开的 1,4-萘醌类似物和激素治疗剂。
• COMPOSITIONS AND METHODS FOR TREATMENT OF PROSTATE CARCINOMA
  申请人：Pellficure Pharmaceuticals, Inc.

  公开号：EP3191087A1

  公开（公告）日：2017-07-19
• [EN] 1,4-QUINONES AND THEIR SULFUR ANALOGUES USEFUL AS LIGANDS OF N-ACETYLTRANSFERASES<br/>[FR] 1,4-QUINONES ET LEURS ANALOGUES SOUFRÉS UTILES EN TANT QUE LIGANDS DE N-ACÉTYLTRANSFÉRASES
  申请人：ISIS INNOVATION

  公开号：WO2011055142A2

  公开（公告）日：2011-05-12

  The invention provides 1,4-quinones, 1,4-naphthoquinones and their sulphur analogues as inhibitors of hNAT1, an enzyme which is both a diagnostic marker and drug target for breast cancer. Some of the compounds of the invention are also chromogenic in the presence of hNAT1. The compounds of the invention are used for detecting for and/or measuring hNAT1 and for inhibiting hNAT1 in the treatment of disease.