4-戊氧基苯基4-反-(4-戊基环己基)苯酸酯 | 780738-23-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 中文名称: 4-戊氧基苯基4-反-(4-戊基环己基)苯酸酯
• 英文名称: 7-Bromo-6-methyl-1,2,3,4-tetrahydroisoquinoline
• CAS: 780738-23-0
• 化学式: C₁₀H₁₂BrN
• 分子量: 226.11
• InChiKey: GLMATKSWEICTPR-UHFFFAOYSA-N

物化性质

• 沸点：
  297.4±40.0 °C(Predicted)
• 密度：
  1.372±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] COMPOSITION AND METHODS OF USE OF TETRAHYDROISOQUINOLINE SMALL MOLECULES TO BIND AND MODULATE PCSK9 PROTEIN ACTIVITY<br/>[FR] COMPOSITION ET PROCÉDÉS D'UTILISATION DE PETITES MOLÉCULES DE TYPE TÉTRAHYDROISOQUINOLINE POUR SE LIER À PCSK9 ET MODULER L'ACTIVITÉ PROTÉIQUE DE PCSK9
  申请人：PORTOLA PHARM INC

  公开号：WO2017034990A1

  公开（公告）日：2017-03-02

  This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small organic compound ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL- cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small organic compound ligands that can raise LDL levels.