(S)-N-(1-naphthylmethyl)-N-(2-pyrrolidinylmethyl)amine | 1146220-30-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-N-(1-naphthylmethyl)-N-(2-pyrrolidinylmethyl)amine
• 英文别名: N-(naphthalen-1-ylmethyl)-1-[(2S)-pyrrolidin-2-yl]methanamine
• CAS: 1146220-30-5
• 化学式: C₁₆H₂₀N₂
• 分子量: 240.348
• InChiKey: DDVRDXMXQZMOLS-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 (S)-N-(1-naphthylmethyl)-N-(2-pyrrolidinylmethyl)amine
  参考文献：
  名称：

  A New Chiral Synthesis of Wieland-Miescher Ketone Catalyzed by a Combination of (S)-N-Benzyl-N-(2-pyrrolidinylmethyl)amine Derivative and Brønsted Acid

  摘要：

  New or known N-benzyl-N-(2-pyrrolidinylmethyl)amine derivatives bearing a variety of substituents on the aromatic ring were easily prepared from N-Boc-proline or N-Boc-prolinol. The enantioselectivity of the intramolecular asymmetric aldol reaction mediated by a combination of the amine derivative and Bronsted acid to prepare Wieland-Miescher ketone was examined in detail. During the examination, remarkable substitutional effects on the aromatic ring were observed. Development of a catalytic version of the reaction was successfully achieved by the use of N-[(9-anthracenyl)methyl]-N-(2-pyrrolidinylmethyl)amine in the presence of dichloroacetic acid.

  DOI：

  10.3987/com-08-s(f)86

文献信息

• IAP BIR domain binding compounds
  申请人：Laurent Alain

  公开号：US20070093428A1

  公开（公告）日：2007-04-26

  Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a salt thereof, in which R 1 , R 2 , R 100 , R 200 , A, A 1 , B, B 1 , BG, n, Q and Q 1 are substituents described. Also disclosed is the use of compounds of Formula 1 to treat proliferative disorders.

  本发明揭示了一种化合物的异构体、对映异构体、顺反异构体或互变异构体，该化合物由公式I表示：或其盐，其中R1、R2、R100、R200、A、A1、B、B1、BG、n、Q和Q1是所描述的取代基。本发明还揭示了利用公式1的化合物治疗增殖性疾病的用途。
• US7589118B2
  申请人：——

  公开号：US7589118B2

  公开（公告）日：2009-09-15