2-(2,2-dimethyl-N-(3-methyl-4-(naphthalen-2-yl)benzyl)chroman-6-sulfonamido)acetic acid | 1331750-06-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(2,2-dimethyl-N-(3-methyl-4-(naphthalen-2-yl)benzyl)chroman-6-sulfonamido)acetic acid
• 英文别名: 2-[(2,2-Dimethyl-3,4-dihydrochromen-6-yl)sulfonyl-[(3-methyl-4-naphthalen-2-ylphenyl)methyl]amino]acetic acid
• CAS: 1331750-06-1
• 化学式: C₃₁H₃₁NO₅S
• 分子量: 529.657
• InChiKey: KKCVIONAMXBMMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  92.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Glycine Chroman-6-Sulfonamides for Use as Inhibitors of Diacylglycerol Lipase
  申请人：Hu Shuanghua

  公开号：US20110207772A1

  公开（公告）日：2011-08-25

  The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity.

  本公开涉及一般可抑制DAGLα和/或β活性的化合物，包括这些化合物的组合物，以及抑制DAGLα和/或β活性的方法。
• GLYCINE CHROMAN-6-SULFONAMIDES FOR USE AS INHIBITORS OF DIACYLGLYCEROL LIPASE
  申请人：Bristol-Myers Squibb Company

  公开号：EP2536704A1

  公开（公告）日：2012-12-26
• Glycine chroman-6-sulfonamides for use as inhibitors of diacylglycerol lipase
  申请人：Bristol-Myers Squibb Company

  公开号：EP2536704B1

  公开（公告）日：2014-01-15
• US8354548B2
  申请人：——

  公开号：US8354548B2

  公开（公告）日：2013-01-15
• [EN] GLYCINE CHROMAN-6-SULFONAMIDES FOR USE AS INHIBITORS OF DIACYLGLYCEROL LIPASE<br/>[FR] GLYCINE-CHROMANE-6-SULFONAMIDES POUR UTILISATION EN TANT QU'INHIBITEURS DE DIACYLGLYCÉROL LIPASE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2011103156A1

  公开（公告）日：2011-08-25

  The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity.