Stilbenyl-(2)-isothiocyanat | 7612-95-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: Stilbenyl-(2)-isothiocyanat
• 英文别名: 2-Isothiocyanato-stilben；1-Isothiocyanato-2-(2-phenylethenyl)benzene
• CAS: 7612-95-5
• 化学式: C₁₅H₁₁NS
• 分子量: 237.325
• InChiKey: NVZXSCLSEHKSAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  44.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• REMEDIES FOR HEART DISEASES
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1426762A1

  公开（公告）日：2004-06-09

  This invention aims at providing a method of searching for substances that can selectively suppress apoptosis in cardiovascular cells. This objective is attained by providing a method of screening for therapeutic and/or prophylactic agents of cardiac disease, which comprises the steps of inducing apoptosis in cultured myocardial cells and/or cultured vascular endothelial cells; treating the cells with a Cl- channel blocker under test; and evaluating the therapeutic and/or prophylactic effect of the blocker under test on cardiac disease by checking to see if it can suppress apoptotic cell death in the cardiovascular cells or vascular endothelial cells.

  本发明旨在提供一种寻找可选择性抑制心血管细胞凋亡物质的方法。 该方法包括以下步骤：在培养的心肌细胞和/或培养的血管内皮细胞中诱导细胞凋亡；用待测的Cl-通道阻滞剂处理细胞；以及通过检查待测阻滞剂是否能抑制心血管细胞或血管内皮细胞中的细胞凋亡，评估其对心脏疾病的治疗和/或预防效果。
• Isothiocyanatostilbenes as a novel method and product for treating cancer
  申请人：BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

  公开号：US10980765B2

  公开（公告）日：2021-04-20

  Products and methods for treating cancer in a human patient comprising administering to the patient therapeutically effective amount of a first pharmaceutically active agent, wherein the first pharmaceutically active agent is one of an isothiocyanatostilbene and a pharmacologically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, or a combination thereof.

  用于治疗人类患者癌症的产品和方法，包括向患者施用治疗有效量的第一种药学活性剂，其中第一种药学活性剂是异硫氰基芪和药理学上可接受的盐、溶液、酯、酰胺、螯合物、立体异构体、对映体、原药或类似物之一，或其组合。
• TREATMENT AND PREVENTION OF EPILEPSY
  申请人：Nedergaard Maiken

  公开号：US20100029613A1

  公开（公告）日：2010-02-04

  The present invention is directed to a method of treating or preventing epileptic seizures in a subject and a method of inhibiting hypersynchronous burst activity of neurons by administering an agent which interferes with glutamate, aspartate, and/or ATP release from astrocytes. Also presented is a method of identifying agents suitable for treating or preventing epileptic seizures.
• ISOTHIOCYANATOSTILBENES AS A NOVEL METHOD AND PRODUCT FOR TREATING CANCER
  申请人：GRAY Alana Lea

  公开号：US20190000791A1

  公开（公告）日：2019-01-03

  Products and methods for treating cancer in a human patient comprising administering to the patient therapeutically effective amount of a first pharmaceutically active agent, wherein the first pharmaceutically active agent is one of an isothiocyanatostilbene and a pharmacologically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, or a combination thereof.
• [EN] ISOTHIOCYANATOSTILBENES AS A NOVEL METHOD AND PRODUCT FOR TREATING CANCER<br/>[FR] ISOTHIOCYANATOSTILBÈNES EN TANT QUE NOUVEAU PROCÉDÉ ET PRODUIT POUR LE TRAITEMENT DU CANCER
  申请人：GRAY ALANA LEA

  公开号：WO2017031036A1

  公开（公告）日：2017-02-23

  Products and methods for treating cancer in a human patient comprising administering to the patient therapeutically effective amount of a first pharmaceutically active agent, wherein the first pharmaceutically active agent is one of an isothiocyanatostilbene and a pharmacologically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, or a combination thereof.