ZINC00135780 | 97738-20-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: ZINC00135780
• 英文别名: 2-(3,4-Dichlor-phenyl)-2,3-dihydro-1H-perimidin；2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-perimidine；2-(3,4-dichlorophenyl)-2,3-dihydro-1H-perimidine
• CAS: 97738-20-0
• 化学式: C₁₇H₁₂Cl₂N₂
• 分子量: 315.202
• InChiKey: PNPZNBSCKVIFFJ-UHFFFAOYSA-N

物化性质

• 沸点：
  541.0±50.0 °C(Predicted)
• 密度：
  1.353±0.06 g/cm3(Predicted)
• 溶解度：
  0.4 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Novel perimidines, their preparation, formulations and use as immunosuppressives
  申请人：ELI LILLY AND COMPANY

  公开号：EP0002906A2

  公开（公告）日：1979-07-11

  Novel 2-aryl-1H-perimidine compounds, which are useful as immunosuppressive agents, are described herein. The compounds are prepared by the condensation of 1,8-diaminonaphthalene with an appropriate acyl compound.

  本文描述了可用作免疫抑制剂的新型 2-芳基-1H-哌啶化合物。这些化合物是通过 1,8-二氨基萘与适当的酰基化合物缩合制备的。
• [EN] INHIBITORS OF ANDROGEN RECEPTOR ACTIVATION FUNCTION-2 (AF2) AS THERAPEUTICS AND METHODS FOR THEIR USE<br/>[FR] INHIBITEURS DE FONCTION D'ACTIVATION DE RÉCEPTEUR D'ANDROGÈNE 2 (AF2) EN TANT QU'AGENTS THÉRAPEUTIQUES ET PROCÉDÉS POUR LEUR UTILISATION
  申请人：UNIV BRITISH COLUMBIA

  公开号：WO2013023300A1

  公开（公告）日：2013-02-21

  This invention provides compound having a structure of Formula ((IA)/(IB)) or Formula ((IIA)/(IIB)) or Formula (III): Formula (IA) or Formula (IB) or Formula (IIA) (IIB) or (III). Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.