5-(2,6-dimethoxyphenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide | 1454666-48-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 5-(2,6-dimethoxyphenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide
• 英文别名: 5-(2,6-dimethoxyphenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-1H-isoquinoline-2-sulfonamide
• CAS: 1454666-48-8
• 化学式: C₁₉H₂₀N₄O₄S₂
• 分子量: 432.524
• InChiKey: ILPSOBRQTOEPKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  130
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] SULFAMIDE SODIUM CHANNEL INHIBITORS<br/>[FR] INHIBITEURS SULFAMIDES DES CANAUX DE SODIUM
  申请人：AMGEN INC

  公开号：WO2013134518A1

  公开（公告）日：2013-09-12

  The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.

  本发明提供了式I的化合物或其药学上可接受的盐，这些化合物是电压门控钠通道的抑制剂，特别是Nav 1.7。这些化合物对于治疗通过抑制钠通道可治疗的疾病，如疼痛障碍，是有用的。还提供了含有本发明化合物的药物组合物。
• Method for separating mandelic compounds in salified form and use of same for preparing aromatic aldehyde
  申请人：RHODIA OPERATIONS

  公开号：US20160318839A1

  公开（公告）日：2016-11-03

  The invention describes a method for separating a mandelic compound in salified form from an aqueous reaction medium resulting from the condensation reaction of a hydroxylated aromatic compound with glyoxylic acid in a basic medium, said method comprising a) decanting said reaction medium in such a way as to recover an organic phase formed from the excess of said aromatic compound and an aqueous phase formed from said mandelic compound and a quantity of the excess of said aromatic compound and b) bringing said aqueous phase into contact with an adsorbent support, resulting in the selective adsorption of said aromatic compound and the recovery of an aqueous flow comprising said mandelic compound in salified form, which is subjected to an oxidation step before being converted into hydroxyaromatic aldehyde by electrodialysis.

  该发明描述了一种从含盐形式的苯甲酸类化合物中分离的方法，该化合物是从在碱性介质中羟基芳香化合物与乙醛酸进行缩合反应所得的水相反应介质中分离出来的。该方法包括a) 将所述反应介质倾析，以便从所述芳香化合物的过量形成的有机相和从所述苯甲酸类化合物及所述芳香化合物的过量量形成的水相中回收；b) 将所述水相与吸附支撑物接触，导致选择性吸附所述芳香化合物并回收含盐形式的所述苯甲酸类化合物的水流，然后在将其转化为羟基芳香醛之前，通过电渗析进行氧化处理。
• PROCEDE DE SEPARATION DE COMPOSES MANDELIQUES SOUS FORME SALIFIEE ET SON UTILISATION POUR LA PREPARATION D'ALDEHYDE AROMATIQUE
  申请人：Rhodia Operations

  公开号：EP3083547B1

  公开（公告）日：2018-09-05
• US9051311B2
  申请人：——

  公开号：US9051311B2

  公开（公告）日：2015-06-09
• US9567283B2
  申请人：——

  公开号：US9567283B2

  公开（公告）日：2017-02-14