N-((E)-2-Naphthalen-2-yl-vinyl)-formamide | 66432-18-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-((E)-2-Naphthalen-2-yl-vinyl)-formamide
• CAS: 66432-18-6
• 化学式: C₁₃H₁₁NO
• 分子量: 197.236
• InChiKey: YALQYUNLOKRBFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.56
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.1
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  3-(2-naphthyl)acrylic acid 生成 N-((E)-2-Naphthalen-2-yl-vinyl)-formamide
  参考文献：
  名称：

  Antibacterial activity of N-(.beta.-styryl)formamides related to tuberin

  摘要：

  A series of para-substituted N-(beta-styryl)formamides, analogues of tuberin (4a), has been prepared and assayed for antibacterial activity. The methylthio, ethoxy, and methyl analogues 4e, 4j, and 4t were about twice as active as tuberin against Mycobacterium phlei. Although tuberin lacks activity against Staphylococcus aureus, several of the analogues described were found to inhibit this organism. The phenyl group of tuberin is not a prerequisite for activity since analogues based on naphthyl or ferrocenyl groups were also active. A quantitative structure-activity relationship further implied that an aromatic group need not be present, suggesting the synthesis of the cyclohexyl and n-amyl analogues which were found to possess high activity.

  DOI：

  10.1021/jm00204a017