(3,5-dichlorophenyl)-[6,8-dimethoxy-1-(3-trifluoromethoxyphenyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone | 848901-03-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (3,5-dichlorophenyl)-[6,8-dimethoxy-1-(3-trifluoromethoxyphenyl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone
• 英文别名: (3,5-dichlorophenyl)-[6,8-dimethoxy-1-[3-(trifluoromethoxy)phenyl]-3,4-dihydro-1H-isoquinolin-2-yl]methanone
• CAS: 848901-03-1
• 化学式: C₂₅H₂₀Cl₂F₃NO₄
• 分子量: 526.339
• InChiKey: MYYFYJSMVRNMQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Novel potassium channels modulators
  申请人：Garcia Gabriel

  公开号：US20050070570A1

  公开（公告）日：2005-03-31

  The invention relates to compounds having the Formula (I) or a salt, or a physiologically functional derivative, or a prodrug thereof, wherein Z is carbonyl or sulfonyl; R 1 is alkyl, alkenyl, alkynyl, aryl, H, halogen, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl or heteroaryl; R 2 is H, OH, —CH 2 —SO 2 -alkyl, —CH 2 —SO 2 -cycloalkyl, —CH 2 —SO 2 -aryl, —CH 2 —SO 2 -heteroaryl, alkylamine, alkenylamine, alkynylamine, cycloalkylamine, arylamine, heteroarylamine, aryl, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl, heteroaryl or a linear or branched alkyl, alkenyl, alkynyl, which can optionally be substituted by one or more substituents R 3 ; R 3 is H, alkyl, alkenyl, alkynyl, cycloalkyl, —CO 2 R 4 , —CONHR 4 , —CONR 4 R 4 , —CR 4 O, —SO 2 R 4 , —NR 4 —CO—R 4 , alkoxy, alkylthio, —OH, —SH, —O-aryl, —O-cycloalkyl, —S-aryl, —S-cycloalkyl, hydroxyalkyl, halogen, haloalkyl, haloalkoxy, CN, NO 2 , hydroxyalkylamine, aminoalkyl, alkylamine, aryl or heteroaryl; R 4 is H, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, alkylthio, —O-aryl, —O-cycloalkyl, OH, SH, —S-aryl, —S-cycloalkyl, hydroxyalkyl, haloalkyl, haloalkoxy, hydroxyalkyl-amine, aminoalkyl, alkylamine, aryl or heteroaryl; R 5 is alkyl, alkenyl or alkynyl.

  该发明涉及具有式（I）的化合物或其盐，或其生理功能衍生物，或其前药，其中Z为羰基或磺酰基；R1为烷基，烯烃基，炔烃基，芳基，氢，卤素，卤代烷基，卤代甲氧基，羟基烷基，环烷基或杂环芳基；R2为氢，羟基，—CH2—SO2-烷基，— —SO2-环烷基，— —SO2-芳基，— —SO2-杂环芳基，烷基胺，烯烃基胺，炔烃基胺，环烷基胺，芳基胺，杂环芳基胺，芳基，卤代烷基，卤代甲氧基，羟基烷基，环烷基，杂环芳基或一个线性或支链烷基，烯烃基，炔烃基，可以选择地被一个或多个取代基R3取代；R3为氢，烷基，烯烃基，炔烃基，环烷基，—CO2R4，—CONHR4，—CONR4R4，—CR4O，—SO2R4，—NR4—CO—R4，烷氧基，烷基硫醚，—羟基，—硫氢，—O-芳基，—O-环烷基，—S-芳基，—S-环烷基，羟基烷基，卤素，卤代烷基，卤代甲氧基，CN，NO2，羟基烷胺，氨基烷基，烷基胺，芳基或杂环芳基；R4为氢，卤素，烷基，烯烃基，炔烃基，环烷基，烷氧基，烷基硫醚，—O-芳基，—O-环烷基，羟基，硫氢，—S-芳基，—S-环烷基，羟基烷基，卤代烷基，卤代甲氧基，羟基烷胺，氨基烷基，烷基胺，芳基或杂环芳基；R5为烷基，烯烃基或炔烃基。
• Cycloalkyl inhibitors of potassium channel function
  申请人：Lloyd John

  公开号：US20050234106A1

  公开（公告）日：2005-10-20

  Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v 1 subfamily of voltage gated K + channels, especially inhibitors K v 1.5 which has been linked to the ultra-rapidly activating delayed rectifier K + current I Kur ), methods of using such compounds in the prevention and treatment of arrhythmia and I Kur -associated conditions, and pharmaceutical compositions containing such compounds.

  新型环烷基化合物，可用作钾通道功能抑制剂（特别是Kv1亚家族电压门控K+通道的抑制剂，特别是与超快速激活延迟整流K+电流IKur相关的Kv1.5抑制剂），使用这种化合物在预防和治疗心律失常和IKur相关疾病方面的方法，以及含有这种化合物的制药组合物。