(1R,2R)-decanoic[2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2-hydroxy-1-pyrrolidin-1-ylmethyl-ethyl]-amide | 491833-31-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: (1R,2R)-decanoic[2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2-hydroxy-1-pyrrolidin-1-ylmethyl-ethyl]-amide
• 英文别名: D-threo-1-phenyI-2-decanoylamino-3-morpholino-1-propanol；N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]decanamide；N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]decanamide
• CAS: 491833-31-9
• 化学式: C₂₅H₄₀N₂O₄
• 分子量: 432.604
• InChiKey: ZZYKVPILOCWOMZ-PXDATVDWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  31
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  71
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
  申请人：Genzyme Corporation

  公开号：US20030050299A1

  公开（公告）日：2003-03-13

  Disclosed is a novel enantiomeric synthesis cermamide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.

  披露了一种新型对映合成UDP葡萄糖：N-酰基鞘氨醇葡糖转移酶抑制剂的方法。同时还披露了在合成过程中形成的新型中间体。
• SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYL TRANSFERASE INHIBITORS
  申请人：GENZYME CORPORATION

  公开号：US20150148534A1

  公开（公告）日：2015-05-28

  Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.

  本发明揭示了一种新的手性合成UDP-葡萄糖：N-酰基鞘氨醇葡萄糖基转移酶抑制剂。同时还揭示了在合成过程中形成的新型中间体。
• SYNTHESIS OF UDP-GLUCOSE: N-ACYLSPHINGOSINE GLUCOSYLTRANSFERASE INHIBITORS
  申请人：Hirth H. Bradford

  公开号：US20080058514A1

  公开（公告）日：2008-03-06

  Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
• US7196205B2
  申请人：——

  公开号：US7196205B2

  公开（公告）日：2007-03-27
• US7265228B2
  申请人：——

  公开号：US7265228B2

  公开（公告）日：2007-09-04