2-(3H-1-(4-chloro-benzenesulfonylamino)-5',7'-dimethoxy-spiro[cyclohexane-4,3'-indene]-1'-yl)-propionic acid | 1151765-95-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(3H-1-(4-chloro-benzenesulfonylamino)-5',7'-dimethoxy-spiro[cyclohexane-4,3'-indene]-1'-yl)-propionic acid
• 英文别名: 2-[4-[(4-Chlorophenyl)sulfonylamino]-5',7'-dimethoxyspiro[cyclohexane-1,3'-indene]-1'-yl]propanoic acid
• CAS: 1151765-95-5
• 化学式: C₂₅H₂₈ClNO₆S
• 分子量: 506.019
• InChiKey: TWEBYVDEGHSXAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• ANTAGONISTS OF PGD2 RECEPTORS
  申请人：Stearns Brian Andrew

  公开号：US20100298368A1

  公开（公告）日：2010-11-25

  Described herein are compounds and pharmaceutical compositions containing such compounds that modulate the PGD 2 activated chemoattractant receptor-homologous molecule expressed on TH 2 cells (CRTH2). Also described herein are methods of using such CRTH2 modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 mediated conditions or diseases.

  本文描述了一些化合物和含有这些化合物的药物组合物，这些化合物能够调节PGD2激活的TH2细胞表达的趋化因子受体同源分子（CRTH2）。本文还描述了使用这种CRTH2调节剂的方法，单独或与其他化合物结合，用于治疗呼吸系统、心血管系统和其他依赖于PGD2或由PGD2介导的疾病或病情。
• [EN] ANTAGONISTS OF PGD2 RECEPTORS<br/>[FR] ANTAGONISTES DE RÉCEPTEURS PGD2
  申请人：AMIRA PHARMACEUTICALS INC

  公开号：WO2009061681A2

  公开（公告）日：2009-05-14

  Described herein are compounds and pharmaceutical compositions containing such compounds that modulate the PGD2 activated chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2). Also described herein are methods of using such CRTH2 modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2 mediated conditions or diseases.