4,5,6,7-Tetrahydro-2-(2-methyl-4-pyridinyl)-2H-pyrazolo[4,3-c]pyridine | 1260896-89-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 4,5,6,7-Tetrahydro-2-(2-methyl-4-pyridinyl)-2H-pyrazolo[4,3-c]pyridine
• 英文别名: 2-(2-methylpyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridine
• CAS: 1260896-89-6
• 化学式: C₁₂H₁₄N₄
• 分子量: 214.27
• InChiKey: KFZKLLASHIQGOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  42.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] PYRIDINYL-SUBSTITUTED PIPERAZINYL OXOETHYL TETRAHYDROPYRAZOLOPYRIDINES<br/>[FR] PIPÉRAZINYL-OXOÉTHYL-TÉTRAHYDROPYRAZOLOPYRIDINES SUBSTITUÉES PAR DU PYRIDINYLE
  申请人：NEUROGEN CORP

  公开号：WO2009100120A2

  公开（公告）日：2009-08-13

  Pyridinyl-substituted piperazinyl oxoethyl tetrahydropyrazolopyridines of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) and other disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).