2-(2,2,3,3,4,4,5,5,6,6-d10-cyclohexanecarbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one | 1246343-37-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 2-(2,2,3,3,4,4,5,5,6,6-d10-cyclohexanecarbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one
• 英文别名: 2-(cyclohexane-2,2,3,3,4,4,5,5,6,6-d10-carbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one；2-(2,2,3,3,4,4,5,5,6,6-decadeuteriocyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
• CAS: 1246343-37-2
• 化学式: C₁₉H₂₄N₂O₂
• 分子量: 322.332
• InChiKey: FSVJFNAIGNNGKK-PFEOQZMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PYRAZINOISOQUINOLINE COMPOUNDS
  申请人：Liu Julie F.

  公开号：US20130029997A1

  公开（公告）日：2013-01-31

  This invention in one embodiment is directed to a compound of Formula Ia; where the designation (R) indicates that the designated carbon has the (R) stereochemistry; and wherein Z 1 is hydrogen or fluorine; Z 2 is hydrogen, deuterium, or fluorine; Z 3 is deuterium; Z 4 is fluorine; m is an integer from 0 to 10; n is an integer from 0 to 2; provided that: the sum of m+n does not exceed 10; and when both Z 1 and Z 2 are hydrogen, the sum of m+n is greater than 0, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering an antihelminthic agent, such as praziquantel.
• US8889687B2
  申请人：——

  公开号：US8889687B2

  公开（公告）日：2014-11-18
• US9206179B2
  申请人：——

  公开号：US9206179B2

  公开（公告）日：2015-12-08
• US9944635B2
  申请人：——

  公开号：US9944635B2

  公开（公告）日：2018-04-17