N-(2-ethylphenyl)-5-phenyl-3-isoxazolecarboxamide | 712347-86-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-ethylphenyl)-5-phenyl-3-isoxazolecarboxamide
• 英文别名: N-(2-ethylphenyl)-5-phenyl-1,2-oxazole-3-carboxamide
• CAS: 712347-86-9
• 化学式: C₁₈H₁₆N₂O₂
• 分子量: 292.3
• InChiKey: RXHMNYZAIKMIJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SMALL MOLECULE INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mtPTP)<br/>[FR] PETITES MOLÉCULES INHIBITRICES DU PORE DE TRANSITION DE PERMÉABILITÉ MITOCHONDRIALE (MTPTP)
  申请人：UNIV KANSAS

  公开号：WO2016073633A1

  公开（公告）日：2016-05-12

  The present technology relates to compounds of any one of Formula I, II, IIa, III, IV, and/or V as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.

  目前的技术涉及到本文描述的任一式I、II、IIa、III、IV和/或V的化合物，以及它们的互变异构体和/或药用盐、组合物以及使用方法。
• Small molecule inhibitors of the mitochondrial permeability transition pore (mtPTP)
  申请人：UNIVERSITY OF KANSAS

  公开号：US10865181B2

  公开（公告）日：2020-12-15

  The present technology relates to compounds of any one of Formula I, II, IIa, III, IV, and/or V as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.

  本技术涉及本文所述的式 I、II、IIa、III、IV 和/或 V 中任何一种的化合物及其同系物和/或药学上可接受的盐、组合物及其使用方法。
• SMALL MOLECULE INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mtPTP)
  申请人：UNIVERSITY OF KANSAS

  公开号：US20220396547A1

  公开（公告）日：2022-12-15

  The present technology relates to compounds of any one of Formula I, II, IIa, III, IV, and/or V as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.