5-(5-fluoro-2-methylphenoxymethyl)-6-[2-methoxy-4-(2-naphthylcarbonyloxy)phenyl]-2,2,4-trimethyl-1,2-dihydroquinoline | 1027099-30-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(5-fluoro-2-methylphenoxymethyl)-6-[2-methoxy-4-(2-naphthylcarbonyloxy)phenyl]-2,2,4-trimethyl-1,2-dihydroquinoline
• 英文别名: [4-[5-[(5-fluoro-2-methylphenoxy)methyl]-2,2,4-trimethyl-1H-quinolin-6-yl]-3-methoxyphenyl] naphthalene-2-carboxylate
• CAS: 1027099-30-4
• 化学式: C₃₈H₃₄FNO₄
• 分子量: 587.691
• InChiKey: KHODXRHELBMQMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  44
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Method for preventing or treating a disease related to the glucocorticoid receptor
  申请人：Matsuda Mamoru

  公开号：US20110275620A1

  公开（公告）日：2011-11-10

  A method for preventing or treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-hydroquinoline compound.

  一种预防或治疗与糖皮质激素受体相关的疾病的方法，涉及给予1,2-羟基喹啉化合物的药理有效剂量。
• NOVEL 1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED PHENYLCHALCOGENO LOWER ALKYL GROUP AND ESTER-INTRODUCED PHENYL GROUP AS SUBSTITUENTS
  申请人：Santen Pharmaceutical Co., Ltd

  公开号：EP2085387B1

  公开（公告）日：2013-04-10
• NOVEL 1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED PHENYLCHALCOGENO LOWER ALKYL GROUP AND ESTER- INTRODUCED PHENYL GROUP AS SUBSTITUENTS
  申请人：Matsuda Mamoru

  公开号：US20100056504A1

  公开（公告）日：2010-03-04

  The compounds represented in general formula (1) and a salt thereof are useful for glucocorticoid receptor modulator. The R 1 represents a hydrogen atom or a lower alkyl group; R 2 represents a hydrogen atom or a lower alkyl group; R 3 and R 4 may be the same or different and represent a hydrogen atom or a lower alkyl group; R 5 represents a hydrogen atom or a lower alkyl group; R 6 represents a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group or a nitro group; X represents —C(O)—, —C(O)NR 8 —, —S(O) 2 — and the like; R 7 and/or R 8 may be the same or different and represent a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, a lower alkoxy group which may have a substituent and the like; Y represents a lower alkylene group; Z represents a chalcogen atom; and P represents 0, 1, 2 or 3.
• US8008496B2
  申请人：——

  公开号：US8008496B2

  公开（公告）日：2011-08-30
• US8440660B2
  申请人：——

  公开号：US8440660B2

  公开（公告）日：2013-05-14