4-氯-7-硝基-1-苯并呋喃 | 76054-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 中文名称: 4-氯-7-硝基-1-苯并呋喃
• 英文名称: 4-chloro-7-nitrobenzofuran
• 英文别名: 4-chloro-7-nitro-1-benzofuran
• CAS: 76054-80-3
• 化学式: C₈H₄ClNO₃
• 分子量: 197.578
• InChiKey: SPBKEYGNLBGTTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  正丙胺 、 4-氯-7-硝基-1-苯并呋喃 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以94%的产率得到7-nitro-N-propylbenzo[c][1,2,5]oxadiazol-4-amine
  参考文献：
  名称：

  Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane

  摘要：

  The design, synthesis and evaluation of a small series of potent amphiphilic norbornane antibacterial agents has been performed (compound 10 MIC = 0.25 mu g/mL against MRSA). Molecular modelling indicates rapid aggregation of this class of antibacterial agent prior to membrane association and insertion. Two fluorescent analogues (compound 29 with 4-amino-naphthalimide and 34 with 4-nitrobenz-2-oxal,3-diazole fluorophores) with good activity (MIC = 0.5 mu g/mL against MRSA) were also constructed and confocal microscopy studies indicate that the primary site of interaction for this family of compounds is the bacterial membrane. (C) 2018 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2018.09.072

文献信息

• A method for manufacturing optically active coumaryl amino acid salts and the coumaryl aminoacid salts thus obtained
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

  公开号：EP1559712A1

  公开（公告）日：2005-08-03

  The present invention relates to the field of the synthesis of optically active amino acids, mainly for the purpose of manufacturing optically active polypeptides that are useful as labelled detection tools. The manufacturing method involves the preparation of optically active coumaryl amino acid salts of formula (I).

  本发明涉及光学活性氨基酸合成领域，主要用于制造作为标记检测工具有用的光学活性多肽。该制造方法涉及制备式(I)的光学活性香豆素氨基酸盐。
• Method for manufacturing optically pure coumaryl amino acids and the novel coumaryl aminoacids thus obtained
  申请人：Garbay Christiane

  公开号：US20070161807A1

  公开（公告）日：2007-07-12

  The present invention relates to the field of the synthesis of optically pure amino acid derivatives, mainly for the purpose of manufacturing optically active polypeptides that are useful as labelled detection tools.

  本发明涉及合成光学纯氨基酸衍生物的领域，主要用于制造作为标记检测工具有用的光学活性多肽。
• Connective tissue growth factor antibodies
  申请人：Fibrogen, Inc.

  公开号：EP2322549A1

  公开（公告）日：2011-05-18

  The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.

  本发明涉及与 CTGF 结合的抗体。这些抗体特别针对 CTGF 中参与纤维化相关生物活动的区域。本发明还涉及使用抗体治疗与 CTGF 相关疾病的方法，包括局部和全身性纤维化疾病，包括肺、肝、心脏、皮肤和肾脏的纤维化疾病。
• Enhancing sensitivity and equimolar detection through modifications of the reaction environment
  申请人：——

  公开号：US20030003503A1

  公开（公告）日：2003-01-02

  This invention provides methods of improving assays for the quantitation of a protein in a sample by enhancing equimolar detection of the protein. Detection is enhanced by modifying the reaction environment of the protein. This invention further provides improved reagent particles for use in the detection and/or quantitation of an analyte in a sample, where the reagent particles comprise two or more coatings of the same or a different substance, such as an antibody, immobilized on an insoluble particle. This invention further provides a method of increasing the sensitivity of particle-enhanced immunoassays by increasing the size of the aggregates that are formed in the assay. Aggregate size is increased by combining the sample with three different antibodies: an analyte-specific antibody immobilized on an insoluble particle, a second antibody specific analyte, and a linker antibody which specifically binds the second antibody but does not bind to the analyte.

  本发明提供了通过加强等摩尔蛋白质检测来改进样品中蛋白质定量分析的方法。通过改变蛋白质的反应环境来提高检测能力。本发明进一步提供了用于检测和/或定量样品中分析物的改进试剂颗粒，其中试剂颗粒包括固定在不溶性颗粒上的两种或两种以上相同或不同物质（如抗体）的涂层。本发明进一步提供了一种通过增大检测中形成的聚集体的尺寸来提高颗粒增强免疫分析灵敏度的方法。将样品与三种不同的抗体（固定在不溶性微粒上的分析物特异性抗体、第二抗体特异性分析物，以及特异性结合第二抗体但不与分析物结合的连接抗体）结合，可增加聚集体的大小。
• CONNECTIVE TISSUE GROWTH FACTOR ANTIBODIES
  申请人：FIBROGEN, INC.

  公开号：EP1631591A2

  公开（公告）日：2006-03-08