1-hydroxy-6,6,9-trimethyl-3-propyl-6H-benzo[c]chromene-2-carboxylic acid | 64846-02-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-hydroxy-6,6,9-trimethyl-3-propyl-6H-benzo[c]chromene-2-carboxylic acid
• 英文别名: 1-Hydroxy-6,6,9-trimethyl-3-propylbenzo[c]chromene-2-carboxylic acid
• CAS: 64846-02-2
• 化学式: C₂₀H₂₂O₄
• 分子量: 326.392
• InChiKey: UTVPXAFTOXQUFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• WGK Germany：
  2

文献信息

• [EN] METHODS FOR CONVERTING TETRAHYDROCANNABINOLIC ACID INTO CANNABINOLIC ACID<br/>[FR] PROCÉDÉS DE CONVERSION DE L'ACIDE TÉTRAHYDROCANNABINOLIQUE EN ACIDE CANNABINOLIQUE
  申请人：CANOPY GROWTH CORP

  公开号：WO2021035342A1

  公开（公告）日：2021-03-04

  Disclosed herein is a method for converting tetrahydrocannabinolic acid (THCA) to cannabinolic acid (CBNA). The method comprises contacting an input material comprising THCA with a benzoquinone reagent under reaction conditions comprising: (i) a reaction temperature that is within a target reaction-temperature range; and (ii) a reaction time that is within a target reaction-time range, to provide an output material in which at least a portion of the THCA from the input material has been converted into CBNA.

  本文揭示了一种将四氢大麻酸（THCA）转化为大麻酸（CBNA）的方法。该方法包括将含有THCA的输入物料与苯醌试剂在反应条件下接触，所述反应条件包括：（i）反应温度在目标反应温度范围内；以及（ii）反应时间在目标反应时间范围内，从而提供输出物料，其中输入物料中的至少一部分THCA已被转化为CBNA。
• [EN] SYNTHESIS OF PHYTOCANNABINOIDS INCLUDING A DEMETHYLATION STEP<br/>[FR] SYNTHÈSE DE PHYTOCANNABINOÏDES COMPRENANT UNE ÉTAPE DE DÉMÉTHYLATION
  申请人：UNIV SYDNEY

  公开号：WO2019033164A1

  公开（公告）日：2019-02-21

  A method for demethylating a methylated phytocannabinoid compound of Formula I to form a phytocannabinoid compound of Formula II: Formula I Formula II wherein: R1 is selected from the group consisting of: substituted or unsubstituted C1-C5 alkyl; R2 is selected from the group consisting of: OH or O, and R3 is selected from the group consisting of: a substituted or unsubstituted cyclohexene, a substituted or unsubstituted C2-C8 alkene, or a substituted or unsubstituted C2-C8 dialkene; or R2 is O, and R2 and R3 together form a ring structure in which R2 is an internal ring atom; wherein the method includes: heating a reaction mixture comprising the methylated phytocannabinoid compounds and a polar aprotic solvent in the presence of a dissolved inorganic alkaline salt for a time sufficient to demethylate at least a portion of the methylated phytocannabinoid compounds and form the phytocannabinoid compound.

  一种去甲基化甲基化植物大麻化合物的方法，形成化学式II的植物大麻化合物：化学式I 化学式II 其中：R1选择自：取代或未取代的C1-C5烷基；R2选择自：OH或O，并且R3选择自：取代或未取代的环己烯，取代或未取代的C2-C8烯烃，或取代或未取代的C2-C8双烯；或者R2为O，且R2和R3一起形成一个环结构，其中R2为内环原子；其中该方法包括：在存在溶解的无机碱性盐的极性无水溶剂中加热反应混合物，以足够时间去甲基化至少一部分甲基化植物大麻化合物并形成植物大麻化合物。
• [EN] METHODS OF SYNTHESIZING HIGH-PURITY CANNABICYCLOL AND ARTIFICIAL RESINS COMPRISING CANNABICYCLOL<br/>[FR] PROCÉDÉS DE SYNTHÈSE DE CANNABICYCLOL DE HAUTE PURETÉ ET RÉSINES ARTIFICIELLES COMPRENANT DE LA CANNABICYCLOL
  申请人：CANOPY GROWTH CORP

  公开号：WO2021127788A1

  公开（公告）日：2021-07-01

  Compositions having enhanced cannabicyclol (CBL) or CBL derivative concentrations are disclosed herein as are methods of synthesizing CBL and CBL derivative in high-purity form. Relative to conventional methods, the methods of the present disclosure may: (i) be better suited to large-scale conditions in that they do not require dangerous and/or toxic solvents and/or reagents; (ii) be more tolerant of complex starting compositions, such as cannabinoid extracts, isolates and/or distillates; (iii) provide CBL and/or CBL derivative at higher yield; (iv) provide easier methods to purify product mixtures comprising CBL and/or CBL derivative; (v) provide product mixtures that comprise unique ratios of CBL or CBL derivative relative to other cannabinoids; (vi) provide product mixtures with reduced THC concentrations and/or (vii) provide artificial resins having of a mixture cannabinoids that cannot be produced by extracting cannabis plant material.

  本文披露了具有增强型大麻环酚（CBL）或CBL衍生物浓度的组合物，以及合成高纯度形式的CBL和CBL衍生物的方法。相对于传统方法，本公开的方法可能：（i）更适合于大规模条件，因为它们不需要危险和/或有毒的溶剂和/或试剂；（ii）更容忍复杂的起始组合物，如大麻提取物、分离物和/或蒸馏液；（iii）提供更高产量的CBL和/或CBL衍生物；（iv）提供更容易纯化含有CBL和/或CBL衍生物的产品混合物的方法；（v）提供相对于其他大麻素具有独特比率的CBL或CBL衍生物的产品混合物；（vi）提供具有降低THC浓度的产品混合物和/或（vii）提供具有无法通过提取大麻植物材料生产的混合大麻素的人工树脂。
• Water soluble compositions comprising purified cannabinoids
  申请人：CANOPY GROWTH CORPORATION

  公开号：US10568865B2

  公开（公告）日：2020-02-25

  This disclosures relates to new compositions and methods for making cannabinoid formulations. In one embodiment, this disclosure provides water soluble compositions comprising a first purified cannabinoid and Vitamin E TPGS. In one embodiment, the disclosure herein comprises a method of making powders comprising heatings material to a first temperature and a second temperature.

  本公开涉及用于制造大麻素制剂的新组合物和方法。在一个实施方案中，本公开提供了包含第一种纯化大麻素和维生素 E TPGS 的水溶性组合物。在一个实施方案中，本公开包括一种制作粉末的方法，包括将材料加热到第一温度和第二温度。
• COMPOSITIONS PURPOSEFULLY SELECTED COMPRISING PURIFIED CANNABINOIDS AND/OR PURIFIED TERPENES
  申请人：Ebbu, LLC

  公开号：US20170266153A1

  公开（公告）日：2017-09-21

  Disclosed herein are new compositions comprising a purified cannabinoid and a purified terpene. In one embodiment, the compositions comprise one or more purified cannabinoids. In one embodiment, the compositions comprise one or more purified cannabinoids in combination with one or more purified terpenes. In one embodiment, the compositions comprise unnaturally occurring ratios. In one embodiment, the compositions comprise unnaturally occurring concentrations. In one embodiment, the compositions comprise unexpected and/or synergistic effects.