N-naphthalenemethyl-3-bromobenzamide | 873329-65-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-naphthalenemethyl-3-bromobenzamide
• 英文别名: N-naphthalen-1-ylmethyl 3-bromobenzamide；3-bromo-N-(naphthalen-1-ylmethyl)benzamide
• CAS: 873329-65-8
• 化学式: C₁₈H₁₄BrNO
• 分子量: 340.219
• InChiKey: TVQFCXYJBNYIJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Alpha-helical mimetics
  申请人：Lessene Guillaume Laurent

  公开号：US20080153802A1

  公开（公告）日：2008-06-26

  Benzoyl urea derivatives that are alpha helical peptides mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting-moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralizing pro-survival Bcl-2 proteins. Use of benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also described.

  公开了模拟α螺旋肽的苯甲酰脲衍生物，这些衍生物模拟BH3-仅蛋白，含有它们的组合物，它们与细胞靶向基团的结合，以及它们在调节细胞死亡中的用途。苯甲酰脲衍生物能够结合并中和促生存的Bcl-2蛋白。还描述了在治疗和/或预防与细胞死亡失调相关的疾病或症状中使用苯甲酰脲衍生物。
• [EN] ALPHA-HELICAL MIMETICS<br/>[FR] MIMÉTIQUES D'HÉLICE ALPHA
  申请人：EARCH THE WALTER AND ELIZA HAL

  公开号：WO2006002474A1

  公开（公告）日：2006-01-12

  Benzoyl urea derivatives that are alpha helical peptide mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralising pro-survival Bcl-2 proteins. Use of the benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also disclosed.

  本文揭示了α螺旋肽类似物的苯甲酰脲衍生物，这些类似物模拟BH3-only蛋白质，包含它们的组合物，它们与细胞靶向基团的结合，以及它们在调控细胞死亡中的用途。苯甲酰脲衍生物能够结合并中和促生存的Bcl-2蛋白。还揭示了苯甲酰脲衍生物在治疗和/或预防与细胞死亡失调相关的疾病或症状中的用途。
• ALPHA-HELICAL MIMETICS
  申请人：THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH

  公开号：EP1763509A1

  公开（公告）日：2007-03-21
• US7956216B2
  申请人：——

  公开号：US7956216B2

  公开（公告）日：2011-06-07