1-(2-p-fluorophenylethyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline | 796869-31-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1-(2-p-fluorophenylethyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline
• 英文别名: 5-[2-(4-fluorophenyl)ethyl]-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline
• CAS: 796869-31-3
• 化学式: C₁₈H₁₈FNO₂
• 分子量: 299.345
• InChiKey: VFZKRZJXDOPDLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(2-p fluorophenylethyl)-6,7-methylenedioxy-3,4-dihydroisoquinoline 在 sodium hydroxide 、 sodium borohydrid 作用下， 以 甲醇 为溶剂， 生成 1-(2-p-fluorophenylethyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline
  参考文献：
  名称：

  Tetrahydroisoquinoline derivatives as melatonin MT2 antagonists

  摘要：

  该发明涵盖了一系列公式I的四氢异喹啉，它们是人体褪黑激素MT2受体的拮抗剂，并可用作生物钟调节剂和睡眠剂。

  公开号：

  US20040235891A1

文献信息

• HYDROXY ALKYL SUBSTITUTED 1,3,8-TRIAZASPIRO 4.5]DECAN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ORL-1 RECEPTOR MEDIATED DISORDERS
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1601674A2

  公开（公告）日：2005-12-07
• [EN] HYDROXY ALKYL SUBSTITUTED 1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ORL-1 RECEPTOR MEDIATED DISORDERS<br/>[FR] DERIVES DE 1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE A SUBSTITUTION HYDROXYALKYLE UTILES POUR TRAITER DES MALADIES ASSOCIEES AU RECEPTEUR ORL-1
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2004022558A2

  公开（公告）日：2004-03-18

  The present invention is directed to novel hydroxy alkyl substituted 1, 3, 8-triazaspiro[4.5]decan-4-one derivatives of the general formula: wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, panic, dementia, mania, bipolar disorder, substance abuse, neuropathic pain, acute pain, chronic pain migraine, asthma, cough, psychosis, schizophrenia, epilepsy, hypertension, obesity, eating disorders, cravings, diabetes, cardiac arrhythmia, irritable bowel syndrome, Crohn's disease, urinary incontinence, adrenal disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, for improved cognition or memory and for mood stabilization.