3-t-Butyl-2-naphthol | 54646-67-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-t-Butyl-2-naphthol
• 英文别名: 3-(tert-Butyl)naphthalen-2-ol；3-tert-butylnaphthalen-2-ol
• CAS: 54646-67-2
• 化学式: C₁₄H₁₆O
• 分子量: 200.28
• InChiKey: QDJWFVOKZOKEQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-t-Butyl-2-naphthol 以 苯 为溶剂， 生成 3'-tert-butyl-4,5,6,7-tetrachlorospiro[1,3-benzodioxole-2,2'-naphthalene]-1'-one
  参考文献：
  名称：

  Novel photoisomerization of spirodienones

  摘要：

  DOI：

  10.1016/s0040-4039(01)80225-2

文献信息

• CONJUGATES OF CEREBLON BINDING COMPOUNDS AND G12C MUTANT KRAS, HRAS OR NRAS PROTEIN MODULATING COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Araxes Pharma LLC

  公开号：US20180015087A1

  公开（公告）日：2018-01-18

  Conjugates of a cereblon-binding compound and compounds having modulatory activity against G12C mutant KRAS, HRAS or NRAS G12C proteins are provided. Methods associated with preparation and use of such conjugates, pharmaceutical compositions comprising such conjugates and methods to modulate the activity of G12C mutant KRAS, HRAS or NRAS G12C proteins for treatment of disorders, such as cancer, are also provided.

  提供了与谷氨酰脑结合化合物和具有调节活性对抗G12C突变KRAS、HRAS或NRAS G12C蛋白的化合物的共轭物。还提供了与制备和使用这种共轭物相关的方法，包括含有这种共轭物的药物组合物以及调节G12C突变KRAS、HRAS或NRAS G12C蛋白活性的方法，用于治疗癌症等疾病。
• THIADIAZOLE ANALOGS THEREOF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED-CONDITIONS
  申请人：AXFORD Jake

  公开号：US20140206661A1

  公开（公告）日：2014-07-24

  The present invention provides a compound of Formula (X) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种公式（X）的化合物或其药用盐；一种制造本发明化合物的方法及其治疗用途。本发明进一步提供了一种药物活性剂的组合物和一种药物组合物。
• COVALENT INHIBITORS OF KRAS G12C
  申请人：Araxes Pharma LLC

  公开号：US20140288045A1

  公开（公告）日：2014-09-25

  Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.

  G12C突变K-Ras蛋白的不可逆抑制剂已提供。还公开了调节G12C突变K-Ras蛋白活性的方法以及通过G12C突变K-Ras蛋白介导的疾病治疗方法。
• Method for producing allyl compound, and ether or ester compound produced thereby
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20040147757A1

  公开（公告）日：2004-07-29

  A method for producing an allyl compound having a compositional formula different from that of an allyl starting material compound, which comprises reacting the allyl starting material compound with an oxygen nucleophilic agent in the presence of a catalyst containing at least one transition metal compound containing a transition metal selected from the group consisting of transition metals belonging to Group 8 to Group 10 of the Periodic Table and a multidentate phosphite compound.

  一种生产具有与烯丙基起始物质化合物不同的组成式的烯丙基化合物的方法，包括在存在至少一种含有从周期表第8组到第10组的过渡金属属于的过渡金属的过渡金属化合物和多齿膦酸酯化合物的催化剂的情况下，将烯丙基起始物质化合物与氧亲核试剂反应。
• [EN] ORGANIC COMPOUND, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE<br/>[FR] COMPOSÉ ORGANIQUE, ÉLÉMENT ÉLECTROLUMINESCENT, DISPOSITIF ÉLECTROLUMINESCENT, DISPOSITIF ÉLECTRONIQUE ET DISPOSITIF D'ÉCLAIRAGE
  申请人：SEMICONDUCTOR ENERGY LAB

  公开号：WO2018203171A1

  公开（公告）日：2018-11-08

  An organic compound has a benzonaphthofuran skeleton and is represented by Formula (G1). In Formula (G1), A represents a pyrene skeleton. In the case where the pyrene skeleton has a substituent, the substituent is a diarylamino group including two substituted or unsubstituted aryl groups each having 6 to 13 carbon atoms, a substituted or unsubstituted aryl group having 6 to 13 carbon atoms, an alkyl group having 1 to 7 carbon atoms, a substituted or unsubstituted monocyclic saturated hydrocarbon group having 3 to 20 carbon atoms, or a substituted or unsubstituted poly cyclic saturated hydrocarbon group having 7 to 10 carbon atoms. The two aryl groups of the diarylamino group may be the same or different. In X1 represented by Formula (G1-1), one of R6 and R7 is bonded to N in Formula (G1), and the other of R6 and R7 represents an alkyl group having 1 to 7 carbon atoms, a substituted or unsubstituted monocyclic saturated hydrocarbon group having 3 to 20 carbon atoms, or a substituted or unsubstituted poly cyclic saturated hydrocarbon group having 7 to 10 carbon atoms.

  一个有苯并萘呋喃骨架的有机化合物，用公式（G1）表示。在公式（G1）中，A代表一个芘骨架。在芘骨架有取代基的情况下，取代基是一个二取代或未取代的芳基氨基基团，每个芳基含有6至13个碳原子，一个取代或未取代的含有6至13个碳原子的芳基，一个含有1至7个碳原子的烷基，一个取代或未取代的含有3至20个碳原子的单环饱和碳氢基团，或一个取代或未取代的含有7至10个碳原子的多环饱和碳氢基团。芳基氨基基团的两个芳基可以相同也可以不同。在由公式（G1-1）表示的X1中，R6和R7中的一个与公式（G1）中的N结合，另一个代表一个含有1至7个碳原子的烷基，一个取代或未取代的含有3至20个碳原子的单环饱和碳氢基团，或一个取代或未取代的含有7至10个碳原子的多环饱和碳氢基团。