2-[[(4-Fluorophenyl)amino]carbonyl]-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid | 152362-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 2-[[(4-Fluorophenyl)amino]carbonyl]-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid
• 英文别名: 5-Benzyloxy-2-(4-fluoro-phenylcarbamoyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid；2-[(4-fluorophenyl)carbamoyl]-6-methoxy-5-phenylmethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
• CAS: 152362-57-7
• 化学式: C₂₅H₂₃FN₂O₅
• 分子量: 450.466
• InChiKey: WISKHMRPXGTZNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  88.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES WITH ANGIOTENSIN II RECEPTOR ANTAGONIST PROPERTIES
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0641326A1

  公开（公告）日：1995-03-08
• METHOD OF TREATMENT OR PROPHYLAXIS INFLAMMATORY PAIN
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：EP1996183A1

  公开（公告）日：2008-12-03
• METHOD OF TREATMENT OR PROPHYLAXIS OF INFLAMMATORY PAIN
  申请人：Smith Maree Therese

  公开号：US20100292159A1

  公开（公告）日：2010-11-18

  This invention discloses the use of angiotensin II receptor 2 (AT 2 receptor) antagonists for the treatment, prophylaxis, reversal and/or symptomatic relief of inflammatory pain, including hyperalgesia, thermal or mechanical allodynia, in vertebrate animals and particularly in human subjects. The AT 2 receptor antagonists may be provided alone or in combination with other compounds such as those that are useful in the control of inflammatory conditions.
• Method of Treatment or Prophylaxis of Inflammatory Pain
  申请人：Spinifex Pharmaceuticals Pty Ltd

  公开号：US20140142116A1

  公开（公告）日：2014-05-22

  A method of treatment, reversal and/or symptomatic relief of inflammatory pain, including hyperalgesia, thermal or mechanical allodynia, in vertebrate animals, particularly in human subjects, comprising administering angiotensin II receptor 2 (AT 2 receptor) antagonists is disclosed. The AT 2 receptor antagonist may be provided alone or in combination with other compounds such as those that are useful in the control of inflammatory pain.
• METHOD OF TREATMENT OR PROPHYLAXIS INFTAMMATORY PAIN
  申请人：Novartis AG

  公开号：US20160052925A1

  公开（公告）日：2016-02-25

  A method of treatment, reversal and/or symptomatic relief of inflammatory pain, including hyperalgesia, thermal or mechanical allodynia, in vertebrate animals, particularly in human subjects, comprising administering angiotensin II receptor 2 (AT 2 receptor) antagonists is disclosed. The AT 2 receptor antagonist may be provided alone or in combination with other compounds such as those that are useful in the control of inflammatory pain.