2-[(E)-styryl]-5-geranylresorcin-1-carboxylic acid | 73436-07-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-[(E)-styryl]-5-geranylresorcin-1-carboxylic acid
• 英文别名: 3-(3,7-Dimethyl-2,6-octadienyl)-2,4-dihydroxy-6-(2；3-[(2E)-3,7-dimethylocta-2,6-dienyl]-2,4-dihydroxy-6-[(E)-2-phenylethenyl]benzoic acid
• CAS: 73436-07-4
• 化学式: C₂₅H₂₈O₄
• 分子量: 392.495
• InChiKey: WHNBKYRXAOMPAE-VSMNQWMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 2-[(E)-styryl]-5-geranylresorcin-1-carboxylic acid 生成 3-((E)-3,7-Dimethyl-octa-2,6-dienyl)-2,4-dihydroxy-6-((E)-styryl)-benzoic acid methyl ester
  参考文献：
  名称：

  Cannabigerol-ähnliche verbindungen aus Helichrysum umbraculigerum

  摘要：

  摘要 对另一种南非蜡菊物种的研究提供了 11 种间苯二酚衍生物，其中大多数与大麻酚和相应的酸密切相关，两者都存在于 H. umbraculigerum 的地上部分。此外，还存在一种新的香叶基查耳酮。这些结构是通过光谱方法和一些化学转化来阐明的。复合材料中大麻酚样化合物的出现令人惊讶。这些化合物中的一些可能是由三种不同的生物遗传途径组合而成的。

  DOI：

  10.1016/0031-9422(79)83025-3

文献信息

• [EN] AMORFRUTIN ANALOGS AS PPARGAMMA-MODULATORS<br/>[FR] ANALOGUES DE L'AMORFRUTINE EN TANT QUE MODULATEURS DE PPARGAMMA
  申请人：MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V

  公开号：WO2014177593A1

  公开（公告）日：2014-11-06

  The present invention relates to Amorfrutin analogues and stereoisomeric forms, solvates, hydrates, conjugates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these Amorfrutin analogues together with pharmaceutically acceptable carrier, excipient and/or diluents. Said Amorfrutin analogues have been identified as modulators of the peroxisome proliferator-activated receptors (PPARs), especially PPARϒ and are useful for the prevention and treatment of metabolic diseases, inflammatory diseases, cancer and preparation of phytomedicals and/or functional food products for prevention of metabolic diseases.

  本发明涉及Amorfrutin类似物和立体异构体形式，以及这些化合物的溶剂结晶体、水合物、结合物和/或药用可接受的盐，以及包含至少一种这些Amorfrutin类似物的药物组合物，与药用可接受的载体、赋形剂和/或稀释剂。所述的Amorfrutin类似物已被确定为过氧化物酶增殖物活化受体（PPARs）的调节剂，特别是PPARϒ，并且对于预防和治疗代谢性疾病、炎症性疾病、癌症以及制备植物药和/或功能性食品产品以预防代谢性疾病是有用的。
• Biosynthesis of phenylpropanoids and phenylpropanoid derivatives
  申请人：EVOLVA SA

  公开号：US10760062B2

  公开（公告）日：2020-09-01

  Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds.

  本文提供了在微生物中生产苯丙类衍生物（如查尔酮和二苯乙烯类）和二氢苯丙类衍生物（如二氢查尔酮和二氢二苯乙烯类）的方法和组合物。特别是，本公开提供了重组微生物及其使用方法，用于生产苯基丙烷类衍生物化合物和二氢苯基丙烷类衍生物化合物。
• Biosynthesis of Phenylpropanoid and Dihydrophenylpropanoid Derivatives
  申请人：EVOLVA SA

  公开号：US20180142216A1

  公开（公告）日：2018-05-24

  Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds.
• MEROTERPENOID COMPOUNDS FOR USE IN THE PREVENTION AND TREATMENT OF A NEUROLOGICAL DISORDER
  申请人：SOCIETE DES PRODUITS NESTLE S.A.

  公开号：US20200405676A1

  公开（公告）日：2020-12-31

  The present invention relates to a compound, in particular a meroterpenoid compound, or salt thereof, for use in the prevention and/or treatment of a neurological disorder in an individual. The compound of the invention can promote lactate secretion. A composition comprising the compound of the invention, and a food or food extract enriched with said compound or composition is also provided.
• [EN] BIOSYNTHESIS OF PHENYLPROPANOID AND DIHYDROPHENYLPROPANOID DERIVATIVES<br/>[FR] BIOSYNTHÈSE DE DÉRIVÉS DE PHÉNYLPROPANOÏDE ET DE DIHYDROPHÉNYLPROPANOÏDE
  申请人：EVOLVA SA

  公开号：WO2016193504A1

  公开（公告）日：2016-12-08

  Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds.