8-(6-aminohexyl)aminoadenosine-5'-triphosphate | 53602-90-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 8-(6-aminohexyl)aminoadenosine-5'-triphosphate
• 英文别名: 8-(6-Aminohexyl)amino-ATP；[[(2R,3S,4R,5R)-5-[6-amino-8-(6-aminohexylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
• CAS: 53602-90-7
• 化学式: C₁₆H₃₀N₇O₁₃P₃
• 分子量: 621.375
• InChiKey: SVIVXJAAFJJUEO-SDBHATRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.2
• 重原子数：
  39
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  317
• 氢给体数：
  9
• 氢受体数：
  19

反应信息

• 作为反应物：
  描述：

  8-(6-aminohexyl)aminoadenosine-5'-triphosphate 、 在 咪唑 、 盐酸 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 反应 34.0h， 生成
  参考文献：
  名称：

  Multifunctional dinucleotide analogs for the generation of complex RNA conjugates

  摘要：

  Oligonucleotide conjugates are needed for in vitro selection schemes aiming at reactions between small, organic reactants. A general strategy is provided for the generation of the required RNA reactant conjugates based on multifunctional dinucleotide analogs. These modified dinucleotides allow for enzymatic ligation to native or enzymatically transcribed RNAs. They further contain a flexible polyethylene glycol spacer for correct spatial positioning and a photolabile cleavage site for selective release. The dinucleotides can be derivatized with the desired organic compounds by activated ester chemistry as was demonstrated by coupling to several nucleobases and nucleotides. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)01114-5

文献信息

• Kit for Highly Sensitive Detection Assays
  申请人：Bade Steffen

  公开号：US20090104633A1

  公开（公告）日：2009-04-23

  The present invention relates to kits comprising 2,4-dichlorophenoxyacetate derivatives as well as antibodies that bind to these derivatives. Inter alia, the kits can be used to label biomolecules for analytical and diagnostic applications. Some of the compounds described here can be used to label biomolecules under physiological conditions and without having to apply in situ activation. Furthermore, the presence of spacers within the 2,4-dichlorophenoxyacetate derivatives improves their binding to antibodies.

  本发明涉及包含2,4-二氯苯氧乙酸衍生物及与其结合的抗体的试剂盒。其中，这些试剂盒可用于标记生物分子以进行分析和诊断应用。这里描述的一些化合物可在生理条件下用于标记生物分子，而无需进行原位激活。此外，2,4-二氯苯氧乙酸衍生物中存在的空间支链改善了它们与抗体的结合。
• Competitive homogeneous Assay
  申请人：AMOCO CORPORATION

  公开号：EP0232967A2

  公开（公告）日：1987-08-19

  Methods and compositions for performing assays for target polynucleotide strands include contacting a sample with a reagent which includes a first and a second poly­nucleotide probe. The first and second probes are capable of assuming a first position wherein the probes are bound to each other and a second position wherein the probes are bound to a target. The probes include label moieties capable of interacting to produce a signal indi­cative of the probes being in one of the two positions.

  对目标多核苷酸链进行检测的方法和组合物包括将样品与试剂接触，试剂包括第一和第二多核苷酸探针。第一探针和第二探针能够处于第一位置（探针相互结合）和第二位置（探针与目标结合）。探针包括标签分子，能够相互作用，产生指示探针处于两个位置之一的信号。
• Novel fluorescent label
  申请人：Bayer Corporation

  公开号：EP0527433A1

  公开（公告）日：1993-02-17

  A fluorescent label compound having the formula         A-B¹-B²-B³-C wherein    A represents the residue of a natural or synthetic nucleotide or nucleoside or a derivative thereof;    B¹ represents a divalent spacer radical or a single bond;    B² represents a divalent spacer radical;    B³ represents a divalent spacer radical or a single bond; and    C represents a coumarin radical having the formula

  一种荧光标签化合物，其化学式为 A-B¹-B²-B³-C 其中 A 代表天然或合成核苷酸或核苷或其衍生物的残基； B¹ 代表二价间隔基或单键 B² 代表二价间隔基； B³ 代表二价间隔基或单键；以及 C 代表具有以下式子的香豆素基
• KIRK, DAVID N.;MILLER, BARRY W., J. CHEM. SOC. PERKIN TRANS. PT 1,(1988) N1, C. 2983-2992
  作者：KIRK, DAVID N.、MILLER, BARRY W.

  DOI：——

  日期：——
• FRAGMENT D'ADN MARQUES A L'UNE AU MOINS DE LEURS EXTREMITES PAR DES RIBONUCLEOTIDES MODIFIES RECONNAISSABLES PAR DES MOLECULES AFFINES ET PROCEDE POUR REALISER UNE ANALYSE DE TELS FRAGMENTS D'ADN
  申请人：INSTITUT PASTEUR

  公开号：EP0097667A1

  公开（公告）日：1984-01-11