(1S,2S)-1,2-bis(4-(dimethylamine)phenyl)ethane-1,2-diamine | 1030609-64-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (1S,2S)-1,2-bis(4-(dimethylamine)phenyl)ethane-1,2-diamine
• 英文别名: (1S,2S)-1,2-di(4-N,N-dimethylaminophenyl)ethylenediamine；(1S,2S)-1,2-bis[4-(dimethylamino)phenyl]ethane-1,2-diamine
• CAS: 1030609-64-3
• 化学式: C₁₈H₂₆N₄
• 分子量: 298.431
• InChiKey: XSUOYNMDPIEXBN-ROUUACIJSA-N

物化性质

• 沸点：
  471.8±45.0 °C(Predicted)
• 密度：
  1.114±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (1S,2S)-1,2-bis(4-(dimethylamine)phenyl)ethane-1,2-diamine 、 2-溴-1,3-二异丙基苯 在 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 、 1,3-双-(2,6-二异丙基苯基)咪唑鎓氯化物 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以61%的产率得到(1S,2S)-1,2-bis[4-(dimethylamino)phenyl]-N,N'-bis[2,6-di(propan-2-yl)phenyl]ethane-1,2-diamine
  参考文献：
  名称：

  一种大位阻氮杂环卡宾钯配合物及其制备方法与应用和基于其的索尼吉布的合成方法

  摘要：

  本发明属于有机合成及化学催化技术领域，公开了一种大位阻氮杂环卡宾钯配合物及其制备方法与其在室温空气条件下高效催化C‑N偶联反应的应用，和基于其的索尼吉布的合成方法。本发明的大位阻氮杂环卡宾钯配合物结构以二苯基咪唑为主配体骨架、官能团化烯丙基为辅助配体，通过在催化剂的金属中心旁边引入官能团化烯丙基作为辅助配体，具有显著提升的催化活性及稳定性，可应用于高效催化C‑N偶联反应，特别是可在室温条件下高效催化C‑N偶联反应，并能得到高达99％的收率。本发明还提供了一种以芳基/脂肪胺、芳基氯代物为反应物，钯催化体系催化下，室温下三步法合成索尼吉布的方法，本发明合成方法步骤少、总收率可高达74.5％。

  公开号：

  CN112209972A

文献信息

• Homogeneous asymmetric hydrogenation catalyst
  申请人：Shimizu Hideo

  公开号：US20090203927A1

  公开（公告）日：2009-08-13

  Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

  提供一种用于均相氢化的有用催化剂，特别是用于均相不对称氢化的催化剂，特别是不对称氢化的催化剂，该催化剂易于获得，在经济性和可操作性方面表现出色，以及一种使用该催化剂产生不饱和化合物的氢化物的方法，特别是使用高产率和光学纯度的该催化剂产生手性活性化合物。
• Optically active transition metal-diamine compound and process for producing optically active alcohol with the same
  申请人：Amano Akira

  公开号：US20070149831A1

  公开（公告）日：2007-06-28

  The present invention provides a water-soluble transition metal-diamine complex which can be easily separated from reaction products through liquid separation, etc. and is recycleable; an optically active diamine compound constituting the ligand of the complex; and a catalyst for asymmetric synthesis which comprises these. The present invention relates to a water-soluble optically active transition metal-diamine complex represented by the formula (2): [wherein R 1 and R 2 each represents hydrogen, a hydrocarbon group, —SO 2 R 13 (wherein R 13 is a hydrocarbon group, substituted amino, etc.), etc.; R 3 to R 12 each represents hydrogen, a hydrocarbon group, alkoxy, substituted amino, etc.; M represents a transition metal; X represents halogen; L represents a ligand; and * indicates an asymmetric carbon atom; provided that at least one of R 3 to R 7 and R 8 to R 12 is substituted amino], a catalyst for asymmetric synthesis containing the complex, and a process for producing an optically active alcohol, which comprises using the catalyst to asymmetrically reduce a ketone.

  本发明提供了一种水溶性过渡金属二胺络合物，可以通过液体分离等方式轻松地与反应产物分离，并且可回收利用；构成络合物配体的手性二胺化合物；以及包括这些化合物的不对称合成催化剂。本发明涉及一种由式（2）表示的水溶性手性过渡金属二胺络合物：[其中R1和R2分别表示氢、烃基、—SO2R13（其中R13是烃基、取代氨基等）、等；R3到R12分别表示氢、烃基、烷氧基、取代氨基等；M表示过渡金属；X表示卤素；L表示配体；*表示手性碳原子；但至少一个R3到R7和R8到R12是取代氨基]，包含该络合物的不对称合成催化剂，以及使用该催化剂将酮不对称还原生产手性醇的方法。
• HYDROGENATION OF ESTERS WITH RU/BIDENTATE LIGANDS COMPLEXES
  申请人：Saudan Lionel

  公开号：US20100286452A1

  公开（公告）日：2010-11-11

  The present invention relates to processes for the reduction by hydrogenation, using molecular H2, of a substrate containing one or two esters, or lactones, functional groups into the corresponding alcohol, or diol, with the process being carried out in the presence of a base and at least one catalyst or pre-catalyst in the form of a ruthenium complex, wherein the ruthenium is coordinated by a diphosphine bidentate ligand (PP ligand) and a diamino bidentate ligand (NN ligand) that includes at least one substituted α-carbon and one primary amine as one of the coordinating atoms.

  本发明涉及一种使用分子氢（H2）对含有一或两个酯类或内酯类官能团的底物进行加氢还原的方法，使其转化为相应的醇或二醇。该方法在碱存在下，至少使用一种钌配合物催化剂或前催化剂，其中钌由二膦双齿配体（PP配体）和一种含有至少一个取代α-碳和一个主要胺基作为配位原子的二胺双齿配体（NN配体）配位。
• HOMOGENEOUS ASYMMETRIC HYDROGENATION CATALYST
  申请人：SHIMIZU Hideo

  公开号：US20110065929A1

  公开（公告）日：2011-03-17

  Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

  提供一种有用的均相加氢催化剂，特别是一种用于均相不对称加氢的催化剂，特别是不对称加氢，该催化剂可以相对容易地获得，并且在经济性和可操作性方面表现出色。同时提供一种使用该催化剂高产率和光学纯度地制备不饱和化合物的氢化物，特别是光学活性化合物的方法。
• Homogeneous Asymmetric Hydrogenation Process
  申请人：SHIMIZU Hideo

  公开号：US20100137615A1

  公开（公告）日：2010-06-03

  Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.

  提供一种有用的均相氢化催化剂，特别是一种用于不对称氢化反应的均相催化剂，该催化剂易于获得，经济实用，易于操作，并且使用该催化剂可以高产率、高光学纯度地制备不饱和化合物的氢化产物，特别是光学活性化合物的氢化产物。