O-(5'-hydroxy-[1,1':4',1''-terphenyl]-2'-yl) (2-methylnaphthalen-1-yl)(phenyl)phosphinothioate | 1579997-20-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: O-(5'-hydroxy-[1,1':4',1''-terphenyl]-2'-yl) (2-methylnaphthalen-1-yl)(phenyl)phosphinothioate
• CAS: 1579997-20-8
• 化学式: C₃₅H₂₇O₂PS
• 分子量: 542.638
• InChiKey: GJYVTMJWKJHQSG-KXQOOQHDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.61
• 重原子数：
  39.0
• 可旋转键数：
  6.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  5'-(((2-methylnaphthalen-1-yl)(phenyl)phosphaneyl)oxy)-[1,1':4',1''-terphenyl]-2'-ol 在 sulfur 作用下， 反应 0.25h， 生成 O-(5'-hydroxy-[1,1':4',1''-terphenyl]-2'-yl) (2-methylnaphthalen-1-yl)(phenyl)phosphinothioate
  参考文献：
  名称：

  Asymmetric Synthesis of P-Stereogenic Diarylphosphinites by Palladium-Catalyzed Enantioselective Addition of Diarylphosphines to Benzoquinones

  摘要：

  The reaction of phenyl(2,4,6-trimethylphenyl)phosphine with a substituted benzoquinone in the presence of a chiral phosphapalladacycle complex as a catalyst and triethylamine in chloroform at -45 degrees C proceeded in a new type of addition manner to give a high yield of a 4-hydroxyphenyl phenyl(2,4,6-trimethylphenyl)phosphinite with 98% enantioselectivity, which is a versatile intermediate readily convertible into various phosphines and their derivatives with high enantiomeric purity.

  DOI：

  10.1021/ja501007t