Cu(CH3COO)2(phen) | 43097-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: Cu(CH3COO)2(phen)
• 英文别名: Cu(CH3COO)2(1,10-phenanthroline)
• CAS: 43097-05-8
• 化学式: C₁₆H₁₄CuN₂O₄
• 分子量: 361.844
• InChiKey: ORPXKKAUYBXPDD-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  1,10-菲罗啉 、 以 乙醇 为溶剂， 以62%的产率得到Cu(CH3COO)2(phen)
  参考文献：
  名称：

  Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: X-ray crystal structures of [Cu(BZA)2(bipy)(H2O)], [Cu(SalH)2(BZDH)2] and [Cu(CH3COO)2(5,6-DMBZDH)2] (SalH2=salicylic acid; BZAH=benzoic acid; BZDH=benzimidazole and 5,6-DMBZDH=5,6-dimethylbenzimidazole)

  摘要：

  A series of simple Cu(II) carboxylate complexes {carboxylate = acetate (CH3COO), salicylate (salH) or benzoate (BZA)}, some containing either one chelating {1,10-phenanthroline (phen) or 2,2 '-bipyridine (bipy)} or two monodentate {benzimidazole (BZDH) or 5,6-dimethylbenzimidazole (5,6-DMBZDH)) nitrogen donor ligands, have been prepared and characterised. X-ray crystal structures have been determined for the square pyramidal complex [Cu(BZA)(2)(bipy)(H2O)] and the two square planar complexes [Cu(CH3COO)(2) (5,6-DMBZDH)(2)] and [Cu(salH)(2)(BZDH)(2)]. All of the complexes are poor catalase mimics in the presence of imidazole and totally inactive in its absence. The complexes all exhibit excellent superoxide dismutase (SOD) mimetic activity and the two phen derivatives [Cu(CH3COO)(2)(phen)] and [Cu(sal)(phen)] display potent in vitro cytotoxicity against human hepatic (Hep-G), renal (A-498) and lung (A-549) cancer cell lines. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2007.05.006