α-6-Deoxy-5-hydroxy-9-methyl-tetracyclin | 59046-79-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 四环素类
• 英文名称: α-6-Deoxy-5-hydroxy-9-methyl-tetracyclin
• 英文别名: 9-Methyl-α-6-desoxy-5-hydroxytetracyclin
• CAS: 59046-79-6
• 化学式: C₂₃H₂₆N₂O₈
• 分子量: 458.468
• InChiKey: KBNKYYHRASVNRR-HHERGWDYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.04
• 重原子数：
  33.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  181.62
• 氢给体数：
  6.0
• 氢受体数：
  9.0

文献信息

• TETRACYCLINE COMPOUNDS HAVING TARGET THERAPEUTIC ACTIVITIES
  申请人：Paratek Pharmaceuticals, Inc.

  公开号：US20180016225A1

  公开（公告）日：2018-01-18

  Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.

  使用具有目标治疗活性的四环素化合物治疗疾病的方法和化合物被描述。
• METHODS OF USING SUBSTITUTED TETRACYCLINE COMPOUNDS TO MODULATE RNA
  申请人：Paratek Pharmaceuticals, Inc.

  公开号：US20150321997A1

  公开（公告）日：2015-11-12

  A method for modulating RNA with tetracycline compounds is described.

  描述了一种用四环素化合物调节RNA的方法。
• Methods of Using Substituted Tetracycline Compounds to Modulate RNA
  申请人：Levy Stuart B.

  公开号：US20120245130A1

  公开（公告）日：2012-09-27

  A method for modulating RNA with tetracycline compounds is described.

  本文描述了一种使用四环素化合物调节RNA的方法。
• SubstitutedTetracycline Compounds for the Treatment of Malaria
  申请人：DRAPER Michael

  公开号：US20120101071A1

  公开（公告）日：2012-04-26

  This invention provides a method for treating or preventing malaria in a subject. The method includes administering to the subject an effective amount of a substituted tetracycline compound, such that malaria is treated or prevented. In one aspect, the invention relates to pharmaceutical compositions which include an effective amount of a tetracycline compound to treat malaria in a subject and a pharmaceutically acceptable carrier. The substituted tetracycline compounds of the invention can be used to in combination with one or more anti-malarial compounds or can be used to treat or prevent malaria which is resistant to one or more other anti-malarial compounds.

  本发明提供了一种治疗或预防疟疾的方法。该方法包括向受试者施用足够量的取代四环素化合物，以治疗或预防疟疾。在一方面，本发明涉及制药组合物，其包括足够量的四环素化合物以治疗受试者的疟疾和药学上可接受的载体。本发明的取代四环素化合物可以与一种或多种抗疟疾化合物结合使用，或者可以用于治疗或预防对一种或多种其他抗疟疾化合物产生耐药性的疟疾。
• Tetracycline compounds for treatment of cryptosporidium parvum related disorders
  申请人：Levy B. Stuart

  公开号：US20070167415A1

  公开（公告）日：2007-07-19

  Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related disorders are also included.