6-chloro-1-fluoromethyl-8-phenylsulfonyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride | 1387000-85-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 6-chloro-1-fluoromethyl-8-phenylsulfonyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride
• 英文别名: 6-Chloro-1-(fluoromethyl)-8-(phenyl sulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride；8-(benzenesulfonyl)-6-chloro-1-(fluoromethyl)-1,2,3,4-tetrahydro-[1]benzofuro[3,2-c]pyridine;hydrochloride
• CAS: 1387000-85-2
• 化学式: C₁₈H₁₅ClFNO₃S*ClH
• 分子量: 416.3
• InChiKey: RNOLCNCWLUUZHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  67.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-Chloro-1-(fluoromethyl)-8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine 、 、 盐酸 以 甲醇 为溶剂， 以to afford 6-chloro-1-(fluoromethyl)-8-(phenyl sulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride (6 mg, 71%, AUC HPLC 96%) as a white solid的产率得到6-chloro-1-fluoromethyl-8-phenylsulfonyl-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride
  参考文献：
  名称：

  BENZOFURO[3,2-c] PYRIDINES AND RELATED ANALOGS AS SEROTONIN SUB-TYPE 6 (5-HT6) MODULATORS FOR THE TREATMENT OF OBESITY, METABOLIC SYNDROME, COGNITION AND SCHIZOPHRENIA

  摘要：

  本发明涉及苯并呋喃[3,2-c]吡啶和氮杂七环类似物作为血清素亚型6（5-HT6）调节剂，包括这些化合物的制药组合物，制备方法以及使用方法。这些化合物在治疗中枢神经系统疾病，包括肥胖症、代谢综合征、认知障碍、精神分裂症、注意力缺陷多动障碍、双相情感障碍、罕见和孤儿病以及睡眠障碍方面具有用途。所述化合物具有公式（I）的结构，其中取代基如下所述。

  公开号：

  US20120184531A1

文献信息

• Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
  申请人：Guzzo Peter R.

  公开号：US09067949B2

  公开（公告）日：2015-06-30

  The present invention relates to benzofuro[3,2-c]pyridine and azepine analogs as serotonin sub-type 6 (5-HT6) modulators, pharmaceutical compositions including these compounds, methods of preparation, and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, schizophrenia, attention deficit hyperactivity disorder, bipolar disorder, rare and orphan diseases, and sleep disorders. The subject compounds have the structure of formula (I) with the substituents being described herein.

  本发明涉及苯并呋喃[3,2-c]吡啶和氮杂七环类似物作为血清素亚型6（5-HT6）调节剂，包括这些化合物的制药组合物，制备方法及其用途。这些化合物在治疗中枢神经系统疾病，包括肥胖症，代谢综合征，认知，精神分裂症，注意力缺陷多动障碍，双相情感障碍，罕见和孤儿疾病以及睡眠障碍方面非常有用。所述化合物具有式（I）的结构，其中取代基在此描述。
• BENZOFURO[3,2-C]PYRIDINES AND RELATED ANALOGS AS SEROTONIN SUB-TYPE 6 (5-HT6) MODULATORS FOR THE TREATMENT OF OBESITY, METABOLIC SYNDROME, COGNITION AND SCHIZOPHRENIA
  申请人：Albany Molecular Research, Inc.

  公开号：EP2668191A2

  公开（公告）日：2013-12-04
• US9067949B2
  申请人：——

  公开号：US9067949B2

  公开（公告）日：2015-06-30
• [EN] BENZOFURO[3,2-C] PYRIDINES AND RELATED ANALOGS AS SEROTONIN SUB-TYPE 6 (5-HT6) MODULATORS FOR THE TREATMENT OF OBESITY, METABOLIC SYNDROME, COGNITION AND SCHIZOPHRENIA<br/>[FR] BENZOFURO[3,2-C]PYRIDINES ET ANALOGUES ASSOCIÉS EN TANT QUE MODULATEURS DU SOUS-TYPE 6 DE LA SÉROTONINE (5-HT6) POUR TRAITEMENT DE L'OBÉSITÉ, DU SYNDROME MÉTABOLIQUE, DE LA COGNITION ET DE LA SCHIZOPHRÉNIE
  申请人：ALBANY MOLECULAR RES INC

  公开号：WO2012099952A2

  公开（公告）日：2012-07-26

  The present invention relates to benzofuro[3,2-c]pyridine and azepine analogs as serotonin sub-type 6 (5-HT6) modulators, pharmaceutical compositions including these compounds, methods of preparation, and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, schizophrenia, attention deficit hyperactivity disorder, bipolar disorder, rare and orphan diseases, and sleep disorders. The subject compounds have the structure of formula (I) with the substituents being described herein.