56Y8HX5N8V | 2244191-80-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 56Y8HX5N8V
• 英文别名: (1R,2R)-2-amino-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-pyrrolidin-1-ylpropan-1-ol;hydrate
• CAS: 2244191-80-6
• 化学式: C15H24N2O4
• 分子量: 296.36
• InChiKey: HYFHOPYHUGNXBX-XRZFDKQNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.09
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  69
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• METHOD FOR SYNTHESIS OF ELIGLUSTAT AND INTERMEDIATE COMPOUNDS THEREOF
  申请人：Zhejiang Ausun Pharmaceutical Co., Ltd.

  公开号：EP3611171A1

  公开（公告）日：2020-02-19

  The present invention relates to a process for synthesis of Eliglustat and intermediate compounds thereof. In particular, the present invention belongs to the field of synthesis of organic compounds, relates to a process for synthesis of Eliglustat and pharmaceutically acceptable salts thereof, and relates to the intermediate compounds used in the process and a process for preparation of the intermediate compounds. Compared with the existing synthetic processes, the process for preparing Eliglustat according to the present invention utilizes novel intermediates and steps for synthesis, has advantages of convenient operations, high yield, good purity of intermediates and desired product, and it is easy to apply the process in the industrial production..

  本发明涉及一种艾格司他及其中间体化合物的合成工艺。具体而言，本发明属于有机化合物合成领域，涉及一种艾格司他及其药学上可接受的盐的合成工艺，并涉及该工艺中使用的中间体化合物以及中间体化合物的制备工艺。与现有的合成工艺相比，根据本发明制备依格司他的工艺利用了新颖的中间体和合成步骤，具有操作方便、收率高、中间体和所需产物纯度好、易于应用于工业生产等优点。
• PROCESS FOR SYNTHESIS OF ELIGLUSTAT AND INTERMEDIATE COMPOUNDS THEREOF
  申请人：ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD.

  公开号：US20200031808A1

  公开（公告）日：2020-01-30

  The present invention relates to a process for synthesis of Eliglustat and intermediate compounds thereof. In particular, the present invention belongs to the field of synthesis of organic compounds, relates to a process for synthesis of Eliglustat and pharmaceutically acceptable salts thereof, and relates to the intermediate compounds used in the process and a process for preparation of the intermediate compounds. Compared with the existing synthetic processes, the process for preparing Eliglustat according to the present invention utilizes novel intermediates and steps for synthesis, has advantages of convenient operations, high yield, good purity of intermediates and desired product, and it is easy to apply the process in the industrial production.