2'-脱氧肌苷5'-三磷酸酯 | 16595-02-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 中文名称: 2'-脱氧肌苷5'-三磷酸酯
• 英文名称: dITP
• 英文别名: 2'-Deoxyinosine triphosphate；[hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate
• CAS: 16595-02-1
• 化学式: C₁₀H₁₅N₄O₁₃P₃
• 分子量: 492.169
• InChiKey: UFJPAQSLHAGEBL-RRKCRQDMSA-N

物化性质

• 密度：
  2.51±0.1 g/cm3(Predicted)
• 物理描述：
  Solid
• LogP：
  -3.355

计算性质

• 辛醇/水分配系数(LogP)：
  -5.5
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  249
• 氢给体数：
  6
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  2'-脱氧肌苷5'-三磷酸酯 在 HCl buffer 、 N-methylhydantoin amidohydrolase 、 potassium chloride 、 尿嘧啶 、 三羟甲基氨基甲烷 、 magnesium chloride 作用下， 反应 0.5h， 生成 2'-Deoxyinosine-5'-diphosphate
  参考文献：
  名称：

  Ogawa, Jun; Nirdnoy, Warawadee; Yamada, Hideaki, Bioscience, Biotechnology and Biochemistry, 1995, vol. 59, # 9, p. 1737 - 1739

  摘要：

  DOI：

文献信息

• PROTON ACCEPTOR IMINIUM/CARBOCATION-TYPE COUPLING AGENTS
  申请人：Albericio Fernando

  公开号：US20100144588A1

  公开（公告）日：2010-06-10

  Novel iminium-type coupling agents containing proton acceptors in their iminium moiety, which can be used beneficially as coupling agents in various chemical polypeptide and/or polynucleotide syntheses, and are particularly useful as yield enhancing and racemization suppressing coupling agents for use in peptide syntheses, are disclosed. Further disclosed are a process of preparing such iminium-type coupling agents and their use in the preparation of polypeptides and/or polynucleotides.

  包含质子受体的新型亚胺型偶联剂，可有益地用作各种化学多肽和/或多核苷酸合成中的偶联剂，并且特别适用于在肽合成中提高产率和抑制旋光异构化的偶联剂。还公开了一种制备这种亚胺型偶联剂的方法以及它们在多肽和/或多核苷酸制备中的用途。
• Fluorescent nucleobase conjugates having anionic linkers
  申请人：PE Corporation (NY)

  公开号：US20020102590A1

  公开（公告）日：2002-08-01

  Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.

  提供了核苷酸染料共轭物和相关化合物，其中染料通过阴离子连接物直接或间接地与核碱基相连。连接物的阴离子性质由连接物中存在的一个或多个阴离子基团提供，例如磷酸酯基、膦酸酯基、磺酸基和羧酸基。当染料作为给体/受体染料对提供时，阴离子连接物可以位于给体和受体之间，或者位于核碱基和给体或受体之间，或两者之间。在一种实施方案中，本发明的共轭物提供了增强的电泳迁移特性，例如，用标记终止子进行二氧基测序的测序片段。
• Polynucleotides active as inducers of interferon production in living
  申请人：Merck & Co., Inc.

  公开号：US04124702A1

  公开（公告）日：1978-11-07

  Polynucleotides which are multistranded are active as inducers of interferon production in living animal cells. They may be: A. Synthetically complexed polymers of two homopolynucleotides. B. A nucleic acid released by phenol from a ribonucleic acid complex elaborated by the growth of Penicillium funiculosum. C. A ribonucleic acid from reovirus type 3 virions. D. Replicative forms of nucleic acids.

  多股聚核苷酸在生物体细胞中作为干扰素产生的诱导剂是活性的。它们可以是：A.由两个同源多聚核苷酸合成的合成复合物。B.由青霉菌菌丝生长制备的核糖核酸复合物中被苯酚释放的核酸。C.从reovirus 3型病毒颗粒中提取的核糖核酸。D.核酸的复制形式。
• Fluorescent Nucleobase Conjugates Having Anionic Linkers
  申请人：TAING Meng

  公开号：US20090092986A1

  公开（公告）日：2009-04-09

  Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.

  提供了核苷酸染料共轭物和相关化合物，其中染料通过阴离子连接基团直接或间接地与核碱基相连。连接基团的阴离子特性由存在于连接基团中的一个或多个阴离子基团提供，例如磷酸酯、膦酸酯、磺酸盐和羧酸盐基团。当染料作为给体/受体染料对提供时，阴离子连接基团可以位于给体和受体之间，或位于核碱基和给体或受体之间，或两者之间。在一种实施例中，本发明的共轭物提供了增强的电泳迁移特性，例如用标记的终止子进行二硫代氧核苷酸测序。
• FLUORESCENT NUCLEOBASE CONJUGATES HAVING ANIONIC LINKERS
  申请人：Taing Meng

  公开号：US20100304381A1

  公开（公告）日：2010-12-02

  Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.

  提供的是核苷酸染料共轭物和相关化合物，其中染料通过阴离子连接剂直接或间接地与核碱基相连。连接剂的阴离子特性由连接剂中存在的一个或多个阴离子基团提供，例如磷酸盐、膦酸盐、磺酸盐和羧酸盐基团。当染料作为给体/受体染料对提供时，阴离子连接剂可以位于给体和受体之间，或位于核碱基和给体或受体之间，或两者之间。在一种实施例中，本发明的共轭物提供了增强的电泳迁移特性，例如使用标记终止子进行二苯基测序的测序片段。