Dicyclohexyl-silandiol | 18027-70-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: Dicyclohexyl-silandiol
• 英文别名: Dicyclohexylsilanediol；dicyclohexyl(dihydroxy)silane
• CAS: 18027-70-8
• 化学式: C₁₂H₂₄O₂Si
• 分子量: 228.407
• InChiKey: NPPCDYNLOPEEJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.08
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Dicyclohexyl-silandiol 在 Br₂ 作用下， 以 溶剂黄146 为溶剂， 生成 hexa-cyclohexyl-cyclotrisiloxane
  参考文献：
  名称：

  Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Si: MVol.C, 102, page 279 - 282

  摘要：

  DOI：
• 作为产物：
  描述：

  二环己基二氯硅烷 在 水 、 三乙胺 作用下， 以 甲基叔丁基醚 、 丙酮 为溶剂， 以68%的产率得到Dicyclohexyl-silandiol
  参考文献：
  名称：

  Silane-based Resins That Can Be Photochemically And/or Thermally Structured, Single-step Method for Their Production, Parent Compounds and Production Methods That Can Be Used for Said Resins

  摘要：

  通过至少部分缩合以下混合物获得可以通过光化学和/或热化学结构化的硅烷树脂：a）至少一种硅烷化合物RaR2bSiX4-a-b，其中R是通过自由基或阳离子聚合可以光化学和/或热化学聚合的有机基团；R2是直链，分支或环状C1-C12烷基基团；X是相同或不同的离去基团；a为1或2；b为0或1；a+b不超过2；和b）至少一种硅醇R12Si（OH）2，其中R1是相同或不同的直链，分支或环状C1-C12烷基基团或通过自由基或阳离子聚合可以光化学和/或热化学聚合的有机基团，但该基团不含芳基。这些硅烷树脂具有在极高频应用中有用的介电性能。

  公开号：

  US20080194856A1

文献信息

• Practical and Selective Bio-Inspired Iron-Catalyzed Oxidation of Si–H Bonds to Diversely Functionalized Organosilanols
  作者：Song Li、Haibei Li、Chen-Ho Tung、Lei Liu

  DOI：10.1021/acscatal.2c02678

  日期：2022.8.5

  oxidant at an iron catalyst loading of 0.1 mol % is reported. The practical and highly selective oxidation exhibits good functional group tolerance, allowing effective access to diversely functionalized alkyl-, aryl-, alkynyl-, and alkoxysilanols, silanediols, as well as mono-, oligo-, and polymeric siloxanols with various substituent patterns. Late-stage gram-scale application in functional-molecule-containing

  功能化有机硅醇已在化学、材料科学和医学领域得到广泛应用。然而，结构多样的有机硅醇的实际合成仍然难以捉摸。在这里，报道了一种受生物启发的非血红素-铁催化的有机硅烷的 Si-H 键的制备氧化，以水过氧化氢作为氧化剂，在 0.1 mol% 的铁催化剂负载下制备多种功能化的有机硅醇。实用且高度选择性的氧化表现出良好的官能团耐受性，允许有效地获得各种官能化的烷基-、芳基-、炔基-和烷氧基硅烷醇、硅烷二醇，以及具有各种取代基模式的单、低聚和聚合硅氧烷醇。进一步证明了在含有功能分子的硅烷醇中的后期克级应用。
• Malignant Peripheral Nerve Sheath Tumors with t(X;18). A Pathologic and Molecular Genetic Study
  作者：Maureen J O'Sullivan、Michael Kyriakos、Xiaopei Zhu、Mark R Wick、Paul E Swanson、Louis P Dehner、Paul A Humphrey、John D Pfeifer

  DOI：10.1038/modpathol.3880230

  日期：2000.11

  Spindle cell sarcomas often present the surgical pathologist with a considerable diagnostic challenge. Malignant peripheral nerve sheath tumor, leiomyosarcoma, fibrosarcoma, and monophasic synovial sarcoma may all appear similar histologically. The application of ancillary diagnostic modalities, such as immunohistochemistry and electron microscopy, may be helpful in the differentiation of these tumors, but in cases in which these adjunctive: techniques fail to demonstrate any more definitive evidence of differentiation, tumor categorization may remain difficult. Cytogenetic and molecular genetic characterization of tumors have provided the basis for the application of molecular assays as the newest components of the diagnostic armamentarium. Because the chromosomal translocation t(X;18) has been observed repeatedly in many synovial sarcomas, it has been heralded as a diagnostic hallmark of synovial sarcoma To formally test the specificity of this translocation for the diagnosis of synovial sarcoma, RNA extracted from formalin-fixed, parrafin-embedded tissue from a variety of soft tissue and spindle cell tumors was evaluated fbr the presence of t(X;18) by reverse transcriptase-polymerase chain reaction. Although 85% of the synovial sarcomas studied demonstrated t(X;18), 75% of the malignant peripheral nerve sheath tumors in our cohort also demonstrated this translocation. We conclude that the translocation t(X;18) is not specific to synovial sarcoma and discuss the implications of the demonstration of t(X;18) in a majority of malignant peripheral nerve sheath tumors.
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Si: MVol.C, 89, page 242 - 246
  作者：

  DOI：——

  日期：——
• Eaborn, C., Journal of the Chemical Society
  作者：Eaborn, C.

  DOI：——

  日期：——
• Lasocki,Z., Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1964, vol. 12, p. 281 - 287
  作者：Lasocki,Z.

  DOI：——

  日期：——