5-fluoro-N2-(indazol-6-yl)-N4-(1,1,3-trioxo-2H,4H-benzo[1,4]thiazin-6-yl)-2,4-pyrimidinediamine | 841289-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 5-fluoro-N2-(indazol-6-yl)-N4-(1,1,3-trioxo-2H,4H-benzo[1,4]thiazin-6-yl)-2,4-pyrimidinediamine
• 英文别名: 6-[[5-fluoro-2-(1H-indazol-6-ylamino)pyrimidin-4-yl]amino]-1,1-dioxo-4H-1lambda6,4-benzothiazin-3-one；6-[[5-fluoro-2-(1H-indazol-6-ylamino)pyrimidin-4-yl]amino]-1,1-dioxo-4H-1λ6,4-benzothiazin-3-one
• CAS: 841289-67-6
• 化学式: C₁₉H₁₄FN₇O₃S
• 分子量: 439.43
• InChiKey: NECUPGYBNZYUKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  150
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• 2,4-Pyrimidinediamine Compounds And Uses As Anti-Proliferative Agents
  申请人：Argade Ankush

  公开号：US20080009484A1

  公开（公告）日：2008-01-10

  The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.
• 2,4-Pyrimidinediamine Compounds and Uses as Anti-Proliferative Agents
  申请人：Argade Ankush

  公开号：US20110190271A1

  公开（公告）日：2011-08-04

  The present invention provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferative diseases such as tumorigenic cancers.
• US7884111B2
  申请人：——

  公开号：US7884111B2

  公开（公告）日：2011-02-08
• US8809341B2
  申请人：——

  公开号：US8809341B2

  公开（公告）日：2014-08-19
• US9598432B2
  申请人：——

  公开号：US9598432B2

  公开（公告）日：2017-03-21