4-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)piperidine | 106898-56-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 二苯并环庚烯
• 英文名称: 4-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)piperidine
• 英文别名: 4-(dibenzosuberane-5-yl)piperidine；4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)piperidine
• CAS: 106898-56-0
• 化学式: C₂₀H₂₃N
• 分子量: 277.409
• InChiKey: NVXZTKZHOTWQJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)piperidine 生成 5-[3-(4-(dibenzosuberane-5-yl)piperidine-1-yl)-2-hydroxypropoxy]quinoline
  参考文献：
  名称：

  Quinoline derivatives

  摘要：

  新颖的杂环化合物，以以下通用公式表示，作为抗癌药物增效剂，对抗癌药物的纳入癌细胞具有增效作用，这些化合物通过例如将由异环化合物与环氧卤水合物反应得到的环氧化合物与胺衍生物反应合成。

  公开号：

  US05112817A1

文献信息

• Compounds having effects on serotonin-related systems
  申请人：Eli Lilly and Company

  公开号：US05741789A1

  公开（公告）日：1998-04-21

  A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1.sub.A receptor. The compounds are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal, and for the treatment of depression and other conditions for which serotonin reuptake inhibitors are used.

  一系列的杂氧烷胺类化合物是治疗与血清素再摄取和血清素1A受体有关或受其影响的疾病的有效药物。这些化合物特别适用于缓解尼古丁和烟草戒断症状，以及治疗抑郁症和其他需要使用血清素再摄取抑制剂的疾病。
• Growth Hormone secretagogues
  申请人：——

  公开号：US20040122234A1

  公开（公告）日：2004-06-24

  This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

  本发明涉及一种新型化合物，该化合物在哺乳动物内调节内源性生长激素水平方面具有用途。本发明还涉及用于合成所述化合物的新型中间体，以及用于这些合成的新型过程。还包括包括给予所述化合物的治疗哺乳动物的方法。
• 4-(5H-Dibenzo[a,d]cyclohepten-5-yl) piperidine compounds
  申请人：Merck & Co., Inc.

  公开号：EP0157399A2

  公开（公告）日：1985-10-09

  Novel 4-(5H-dibenzo[a,d]cyclohepten-5-yl)-piperidine compounds of the formula: are disclosed wherein the bond designation between the 10 and 11 positions indicates that the bond may be a saturated single bond or an unsaturated double bond, X is hydrogen, halogen, trifluoromethyl or lower alkoxy; R is, e.g., selected from the group consisting of: a) a substituted aralkyl group represented by the formula: wherein A is di(lower alkyl)amino or lower alkoxy; b) an aralkenyl group represented by the formula: where D is lower alkoxy; c) a nitrogen containing alkyl group represented by the formula: wherein Y is -CN, or d) an acyl group represented by the formula: wherein R' is lower alkyl, substituted lower alkyl, phenyl or substituted phenyl, styryl or substituted styryl; and acid addition salts thereof. The compounds have the property of inhibiting calcium induced contraction of the smooth muscle.

  式中的新型 4-(5H-二苯并[a,d]环庚烯-5-基)-哌啶化合物： 其中 10 和 11 位置之间的键表示该键可以是饱和单键或不饱和双键、 X 是氢、卤素、三氟甲基或低级烷氧基； R是，例如，选自由下列组成的组 a) 取代的芳烷基，由式表示： 其中 A 是二(低级烷基)氨基或低级烷氧基； b) 式中 D 代表低级烷氧基的芳烷基 其中 D 是低级烷氧基 c) 含氮烷基，由式表示： 其中 Y 为-CN、 或 d) 式中 R'为低级烷基、取代的低级烷基、苯基或取代的苯基的酰基： 其中 R'是低级烷基、取代的低级烷基、苯基或取代的苯基、苯乙烯基或取代的苯乙烯基； 及其酸加成盐。 这些化合物具有抑制钙诱导的平滑肌收缩的特性。
• Congestive heart failure treatment
  申请人：ELI LILLY AND COMPANY

  公开号：EP0898963A2

  公开（公告）日：1999-03-03

  The invention provides methods for the modulation of cardiac function by the administration of a growth hormone secretagogue, which results in an increase in the levels of endogenous growth hormone. Also provided are methods for the treatment of congestive heart failure by the administration of a growth hormone secretagogue. Further provided are methods for the treatment of congestive heart failure by the administration of a growth hormone secretagogue in combination with a growth hormone releasing hormone, or in combination with an antihypertensive agent, diuretic, or other suitable agents.

  本发明提供了通过服用生长激素促泌剂来调节心脏功能的方法，这种促泌剂可提高内源性生长激素的水平。本发明还提供了通过服用生长激素分泌物治疗充血性心力衰竭的方法。此外，还提供了通过服用生长激素促泌剂与生长激素释放激素联合，或与降压药、利尿剂或其他合适的药物联合，治疗充血性心力衰竭的方法。
• Growth hormone secretagogues
  申请人：ELI LILLY AND COMPANY

  公开号：EP0933365A2

  公开（公告）日：1999-08-04

  This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

  本发明涉及可用于调节哺乳动物体内内源性生长激素水平的新型化合物。本发明还涉及用于合成上述化合物的新型中间体，以及用于这些合成的新型工艺。本发明还包括治疗哺乳动物的方法，其中包括施用上述化合物。