3-carbamoylisoxazol-5-ylmethyl (+)-(S)-3-(naphth-2-yloxy-methyl)pyrrolidine-1-carboxylate | 1315548-20-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-carbamoylisoxazol-5-ylmethyl (+)-(S)-3-(naphth-2-yloxy-methyl)pyrrolidine-1-carboxylate
• 英文别名: (3-carbamoyl-1,2-oxazol-5-yl)methyl (3S)-3-(naphthalen-2-yloxymethyl)pyrrolidine-1-carboxylate
• CAS: 1315548-20-9
• 化学式: C₂₁H₂₁N₃O₅
• 分子量: 395.415
• InChiKey: BXXCDMVMBLIOCP-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] ALKYL-HETEROCYCLE CARBAMATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION<br/>[FR] DÉRIVÉS CARBAMATES ALKYL-HÉTÉROCYCLIQUES, LEUR PRÉPARATION ET LEUR APPLICATION THÉRAPEUTIQUE
  申请人：SANOFI AVENTIS

  公开号：WO2011089550A1

  公开（公告）日：2011-07-28

  The invention relates to compounds corresponding to the general formula (I) : in which R2 represents a hydrogen, fluorine, hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy or -NR8R9; n and m represent, independently of one another, an integer equal to 1, 2 or 3, it being understood that the sum m+n is at most equal to 5; A represents a covalent bond, an oxygen, a C1-6-alkylene or -O-C1-6-alkylene; R1 represents a phenyl or a heterocycle which is optionally substituted; R3 represents a hydrogen, fluorine, C1-6-alkyl or trifluoromethyl; R4 represents an optionally substituted 5-membered heterocycle; in the form of the base or of an addition salt with an acid; with the exclusion of 5-methylisoxazol-3-ylmethyl 4-hydroxy-4- (4- chlorophenyl) piperidine-1-carboxylate. The invention also relates to a process for the preparation of the compounds of formula (I), to compositions comprising them and to their therapeutic application.

  本发明涉及与通式（I）相对应的化合物： 其中，R2表示氢、氟、羟基、氰基、三氟甲基、C1-6烷基、C1-6烷氧基或-NR8R9；n和m分别表示等于1、2或3的整数，其中m+n的总和最多等于5；A表示共价键、氧、C1-6-烷基亚甲基或-O-C1-6-烷基亚甲基；R1表示苯基或可选取代的杂环；R3表示氢、氟、C1-6烷基或三氟甲基；R4表示可选取代的5-成员杂环；以碱或酸的加成盐的形式存在。 本发明还涉及制备通式（I）化合物的方法、包含它们的组合物以及它们的治疗应用，但不包括5-甲基异噁唑-3-基甲基4-羟基-4-（4-氯苯基）哌啶-1-羧酸酯。