N,N'-二丹磺酰-L-胱氨酸 | 18468-46-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: N,N'-二丹磺酰-L-胱氨酸
• 中文别名: N,N'-二1－二甲胺基萘－5－磺酰-L-胱氨酸
• 英文名称: Di(dansyl)cystine
• 英文别名: (2R)-3-[[2-carboxy-2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]ethyl]disulfanyl]-2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]propanoic acid
• CAS: 18468-46-7
• 化学式: C₃₀H₃₄N₄O₈S₄
• 分子量: 706.9
• InChiKey: MGNAZESEUVNMRR-UXMRNZNESA-N

物化性质

• 沸点：
  899.2±75.0 °C(Predicted)
• 密度：
  1.473±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  46
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  241
• 氢给体数：
  4
• 氢受体数：
  14

文献信息

• NANOCOMPLEXES OF MODIFIED PEPTIDES OR PROTEINS
  申请人：Tufts University

  公开号：US20160129120A1

  公开（公告）日：2016-05-12

  A nanocomplex containing a delivery agent and a pharmaceutical agent. The nanocomplex has a particle size of 50 to 1000 nm, the delivery agent binds to the pharmaceutical agent via non-covalent interaction or covalent bonding, and the pharmaceutical agent is a modified peptide or protein formed of a peptide or protein and an added chemical moiety that contains an anionic group, a disulfide group, a hydrophobic group, a pH responsive group, a light responsive group, a reactive oxygen species responsive group, or a combination thereof.

  一种纳米复合物，包含传递剂和药物剂。该纳米复合物的粒径为50至1000纳米，传递剂通过非共价作用或共价键合与药物剂结合，药物剂是一种修饰的肽或蛋白质，由肽或蛋白质和含有负离子基团、二硫键基团、疏水基团、pH响应基团、光响应基团、反应性氧化物种响应基团或其组合的添加化学基团组成。
• Process for reducing contaminating Michael acceptor levels in oxycodone and other compositions
  申请人：Shafer A. Jules

  公开号：US20070149559A1

  公开（公告）日：2007-06-28

  The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.

  本发明涉及从某些组合物中去除Michael受体的过程，其中所述组合物经过含硫醇化合物的处理，以足够的条件去除Michael受体和所得的硫醇-Michael加合物。本发明的某些实施例使得可以量化和/或去除Michael受体和/或Michael受体前体。
• PROCESS FOR REDUCING CONTAMINATING MICHAEL ACCEPTOR LEVELS IN OXYCODONE AND OTHER COMPOSITIONS
  申请人：Shafer Jules A.

  公开号：US20110136849A1

  公开（公告）日：2011-06-09

  The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.

  本发明涉及一种从某些组合物中去除Michael受体的过程，其中该组合物经过用含硫醇化合物处理的条件足以去除Michael受体和所得的硫醇-Michael加合物。本发明的某些实施例使得可以量化和/或去除Michael受体和/或Michael受体前体。
• Processes for reducing contaminating Michael acceptor levels in oxycodone and other compositions
  申请人：Controlled Chemicals, Inc.

  公开号：EP2402346A1

  公开（公告）日：2012-01-04

  The present invention relates to processes for removal of Michael acceptors from certain compositions wherein the composition is treated with a thiol-containing compound under conditions sufficient to remove Michael acceptors and the resulting thiol-Michael adducts. Certain embodiments of the present invention enable quantification and/or removal of Michael acceptors and/or Michael acceptor precursors.

  本发明涉及从某些组合物中去除迈克尔受体的工艺，其中用含硫醇的化合物在足以去除迈克尔受体和由此产生的硫醇-迈克尔加合物的条件下处理组合物。本发明的某些实施方案可以定量和/或去除迈克尔受体和/或迈克尔受体前体。
• Mixed charge copolymers and hydrogels
  申请人：University of Washington

  公开号：US10301413B2

  公开（公告）日：2019-05-28

  Nonfouling copolymers and hydrogels comprising positively charged repeating units or latent positively charged repeating units and negatively charged units or latent positively charged units.

  由带正电的重复单元或潜在带正电的重复单元和带负电的单元或潜在带正电的单元组成的防污共聚物和水凝胶。