1-(2,5-Dimethyl-phenyl)-2-(2-phenethyl-phenyl)-ethanone | 134030-81-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(2,5-Dimethyl-phenyl)-2-(2-phenethyl-phenyl)-ethanone
• 英文别名: 1-(2,5-Dimethylphenyl)-2-[2-(2-phenylethyl)phenyl]ethanone
• CAS: 134030-81-2
• 化学式: C₂₄H₂₄O
• 分子量: 328.454
• InChiKey: ZQZBUCXMGLVVEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(2-phenylethyl)phenylacetic acid 在 Nafion-H 作用下， 以 xylene 为溶剂， 反应 12.0h， 以59%的产率得到1-(2,5-Dimethyl-phenyl)-2-(2-phenethyl-phenyl)-ethanone
  参考文献：
  名称：

  Organic reactions catalyzed by solid superacids. 5. Perfluorinated sulfonic acid resin (Nafion-H) catalyzed intramolecular Friedel-Crafts acylation

  摘要：

  Nafion-H, a perfluorinated sulfonic acid resin, catalyzed the intramolecular Friedel-Crafts acylation of diarylalkane-2-carboxylic acids and arylalkanoic acids in refluxing p-xylene to provide cyclic ketones. The reactions were clean, and the water that was formed as a byproduct did not deactivate the catalyst. It was also found that the intramolecular acylation of the corresponding acid chlorides occurred under much milder reaction conditions. The mechanism of the reaction is discussed.

  DOI：

  10.1021/jo00012a033

文献信息

• YAMATO, TAKEHIKO;HIDESHIMA, CHIEKO;PRAKASH, G. K. SURYA;OLAH, GEORGE A., J. ORG. CHEM., 56,(1991) N2, C. 3955-3957
  作者：YAMATO, TAKEHIKO、HIDESHIMA, CHIEKO、PRAKASH, G. K. SURYA、OLAH, GEORGE A.

  DOI：——

  日期：——